Rabbit anti-Human, Mouse TXNDC12 Polyclonal Antibody | anti-TXNDC12 antibody
TXNDC12, CT (TXNDC12, TLP19, Thioredoxin domain-containing protein 12, Endoplasmic reticulum resident protein 18, Endoplasmic reticulum resident protein 19, Thioredoxin-like protein p19, hTLP19) (Azide free) (HRP)
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.
Western Blot (WB)
(Western blot analysis of TXNDC12 Antibody (C-term) in Y79 cell line lysates (35ug/lane). TXNDC12 (arrow) was detected using the purified Pab.)
Western Blot (WB)
(Western blot analysis of TXNDC12 Antibody (C-term) in mouse stomach tissue lysates (35ug/lane). TXNDC12 (arrow) was detected using the purified Pab.)
Immunohistochemistry (IHC)
(TXNDC12 Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded prostate carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the TXNDC12 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Uniprot Description
TXNDC12: Possesses significant protein thiol-disulfide oxidase activity.
Protein type: EC 1.8.4.2; Secreted; Other Amino Acids Metabolism - glutathione; Secreted, signal peptide; Oxidoreductase
Chromosomal Location of Human Ortholog: 1p32.3
Cellular Component: endoplasmic reticulum lumen
Molecular Function: protein-disulfide reductase (glutathione) activity
Biological Process: cell redox homeostasis