Rabbit anti-Human, Mouse TREML1 Polyclonal Antibody | anti-TREML1 antibody

TREML1, CT (TREML1, TLT1, Trem-like transcript 1 protein, Triggering receptor expressed on myeloid cells-like protein 1) (FITC)

Cat. Num. AAA6358058

• Gene Names: TREML1; TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TREML1; Polyclonal Antibody; CT (TREML1; TLT1; Trem-like transcript 1 protein; Triggering receptor expressed on myeloid cells-like protein 1) (FITC); Triggering receptor expressed on myeloid cells-like protein 1; anti-TREML1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-TREML1 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TREML1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-241 amino acids from the C-terminal region of human TREML1.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TREML1 Antibody (C-term) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the TREML1 antibody detected the TREML1 protein (arrow).)

Western Blot (WB)

(TREML1 Antibody (C-term) western blot analysis in mouse spleen tissue lysates (35ug/lane).This demonstrates the TREML1 antibody detected the TREML1 protein (arrow).)

Related Product Information for anti-TREML1 antibody

TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1 (MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. TREML1 enhances calcium signaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003 [PubMed 12645956]; Barrow et al., 2004 [PubMed 15128762]).[supplied by OMIM].

Product Categories/Family for anti-TREML1 antibody

Antibodies; Receptors

References

Morales, J., et al. Blood Coagul. Fibrinolysis 21(3):229-236(2010). Washington, A.V., et al. J. Clin. Invest. 119(6):1489-1501(2009). Ford, J.W., et al. Curr. Opin. Immunol. 21(1):38-46(2009). Nurden, A.T., et al. Thromb. Haemost. 100(1):45-51(2008). Giomarelli, B., et al. Thromb. Haemost. 97(6):955-963(2007).

NCBI and Uniprot Product Information

• NCBI GI #: 30794266
• NCBI GeneID: 340205
• NCBI Accession #: NP_835468.1
• NCBI GenBank Nucleotide #: NM_178174.3
• UniProt Accession #: Q86YW5; Q496B3; Q8IWY1; Q8IWY2
• Molecular Weight: 20,731 Da
• NCBI Official Full Name: trem-like transcript 1 protein isoform a
• NCBI Official Synonym Full Names: triggering receptor expressed on myeloid cells like 1
• NCBI Official Symbol: TREML1
• NCBI Official Synonym Symbols: TLT1; TLT-1; PRO3438; GLTL1825; dJ238O23.3
• NCBI Protein Information: trem-like transcript 1 protein
• UniProt Protein Name: Trem-like transcript 1 protein
• Protein Family: Trem-like transcript 1 protein
• UniProt Gene Name: TREML1
• UniProt Synonym Gene Names: TLT1; TLT-1
• UniProt Entry Name: TRML1_HUMAN

NCBI Description

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]

Uniprot Description

TREML1: Cell surface receptor that may play a role in the innate and adaptive immune response. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.1

Cellular Component: plasma membrane

Biological Process: regulation of immune response