Rabbit anti-Human SYTL4 Polyclonal Antibody | anti-SYTL4 antibody

SYTL4, NT (SYTL4, Synaptotagmin-like protein 4, Exophilin-2, Granuphilin) (MaxLight 650)

Cat. Num. AAA6353113

• Gene Names: SYTL4; SLP4
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SYTL4; Polyclonal Antibody; NT (SYTL4; Synaptotagmin-like protein 4; Exophilin-2; Granuphilin) (MaxLight 650); Granuphilin; anti-SYTL4 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.

• Applicable Applications for anti-SYTL4 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SYTL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5-34 amino acids from the N-terminal region of human SYTL4.
• Conjugate: MaxLight650
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Related Product Information for anti-SYTL4 antibody

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein.

Product Categories/Family for anti-SYTL4 antibody

Antibodies; Syntaxin; Synaptotagmin; Synaptophysin

References

Plaisance, V., et al. J. Biol. Chem. 281(37):26932-26942(2006). Ciufo, L.F., et al. Mol. Biol. Cell 16(2):470-482(2005). Fukuda, M. J. Biol. Chem. 278(17):15390-15396(2003). Fukuda, M., et al. J. Biol. Chem. 277(42):39673-39678(2002). Torii, S., et al. Mol. Cell. Biol. 22(15):5518-5526(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 193804860
• NCBI GeneID: 94121
• NCBI Accession #: NP_542775.2
• NCBI GenBank Nucleotide #: NM_080737.2
• UniProt Accession #: Q96C24; Q5H9J3; Q5JPG8; Q8N9P4; Q9H4R0; Q9H4R1
• Molecular Weight: 39,813 Da
• NCBI Official Full Name: synaptotagmin-like protein 4
• NCBI Official Synonym Full Names: synaptotagmin like 4
• NCBI Official Symbol: SYTL4
• NCBI Official Synonym Symbols: SLP4
• NCBI Protein Information: synaptotagmin-like protein 4
• UniProt Protein Name: Synaptotagmin-like protein 4
• Protein Family: Synaptotagmin-like protein
• UniProt Gene Name: SYTL4
• UniProt Entry Name: SYTL4_HUMAN

NCBI Description

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

Uniprot Description

SYTL4: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: Xq21.33

Cellular Component: nucleoplasm; centrosome; synaptic vesicle; extrinsic to membrane; cytoplasm; plasma membrane; endosome; secretory granule

Molecular Function: zinc ion binding; transporter activity; neurexin binding; phospholipid binding; Rab GTPase binding

Biological Process: intracellular protein transport; exocytosis; positive regulation of protein secretion; negative regulation of insulin secretion; positive regulation of exocytosis