Rabbit anti-Human SUOX Polyclonal Antibody | anti-SUOX antibody

SUOX, ID (SUOX, Sulfite oxidase, mitochondrial) (AP)

Cat. Num. AAA6352621

• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: SUOX; Polyclonal Antibody; ID (SUOX; Sulfite oxidase; mitochondrial) (AP); mitochondrial; anti-SUOX antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-SUOX antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: SUOX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 159-187 amino acids from the Central region of human SUOX.
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(SUOX Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the SUOX antibody detected the SUOX protein (arrow).)

Related Product Information for anti-SUOX antibody

Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins.

Product Categories/Family for anti-SUOX antibody

Antibodies; Enzymes; Oxidase

References

Rajapakshe, A., et al. Biochemistry 49(25):5154-5159(2010). Johnson-Winters, K., et al. Biochemistry 49(6):1290-1296(2010). Neumann, M., et al. FEBS J. 275(22):5678-5689(2008). Astashkin, A.V., et al. J. Am. Chem. Soc. 130(26):8471-8480(2008). Hakonarson, H., et al. Diabetes 57(4):1143-1146(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 74099704
• NCBI GeneID: 6821
• NCBI Accession #: NP_001027559.1; NP_001027558.1
• NCBI GenBank Nucleotide #: NM_001032387.1
• UniProt Accession #: P51687
• Molecular Weight: 60,283 Da
• NCBI Official Full Name: sulfite oxidase, mitochondrial
• NCBI Official Synonym Full Names: sulfite oxidase
• NCBI Official Symbol: SUOX
• NCBI Protein Information: sulfite oxidase, mitochondrial
• UniProt Protein Name: Sulfite oxidase, mitochondrial
• Protein Family: Sulfite oxidase
• UniProt Gene Name: SUOX
• UniProt Entry Name: SUOX_HUMAN

Uniprot Description

SUOX: Defects in SUOX are the cause of isolated sulfite oxidase deficiency (ISOD); also known as sulfocysteinuria. ISOD is characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age.

Protein type: Mitochondrial; Energy Metabolism - sulfur; Oxidoreductase; EC 1.8.3.1

Chromosomal Location of Human Ortholog: 12q13.2

Cellular Component: mitochondrial matrix; mitochondrial intermembrane space

Molecular Function: molybdopterin cofactor binding; electron carrier activity; molybdenum ion binding; heme binding; sulfite oxidase activity

Biological Process: sulfur amino acid metabolic process; sulfur amino acid catabolic process

Disease: Sulfocysteinuria