Rabbit anti-Human, Mouse SUOX Polyclonal Antibody | anti-SUOX antibody

SUOX (Sulfite Oxidase, Mitochondrial)

Cat. Num. AAA646167

• Reactivity: Human, Mouse
• Applications: Western Blot, Immunoprecipitation
• Purity: Serum; Serum
• Synonyms: SUOX; Polyclonal Antibody; SUOX (Sulfite Oxidase; Mitochondrial); Anti -SUOX (Sulfite Oxidase; anti-SUOX antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human SUOX. Species Crossreactivity: mouse.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid.
• Sequence: MGTLLGLGAVLAYQDHRCRAAQESTHIYTKEEVSSHTSPETGIWVTLGSEVFDVTEFVDLHPGGPSKLMLAAGGPLEPFWALYAVHNQSHVRELLAQYKIGELNPEDKVAPTVETSDPYADDPVRHPALKVNSQRPFNAEPPPELLTENYITPNPIFFTRNHLPVPNLDPDTYRLHVVGAPGGQSLSLSLDDLHNFPRYEITVTLQCAGNRRSEMTQVKEVKGLEWRTGAISTARWAGARLCDVLAQAGHQLCETEAHVCFEGLDSDPTGTAYGASIPLARAMDPEAEVLLAYEMNGQPLPRDHGFPVRVVVPGVVGARHVKWLGRVSVQPEESYSHWQRRDYKGFSPSVDWETVDFDSAPSIQELPVQSAITEPRDGETVESGEVTIKGYAWSGGGRAVIRVDVSLDGGLTWQVAKLDGEEQRPRKAWAWRLWQLKAPVPAGQKELNIVCKAVDDGYNVQPDTVAPIWNLRGVLSNAWHRVHVYVSP

• Applicable Applications for anti-SUOX antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blot and Immunoprecipitation.
• Immunogen: Full length human SUOX, aa1-488 (ENSP00000348440).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(SUOX rabbit polyclonal antibody. Western Blot analysis of SUOX expression in human liver.)

Western Blot (WB)

(SUOX rabbit polyclonal antibody. Western Blot analysis of SUOX expression in mouse liver.)

Western Blot (WB)

(Western Blot analysis of SUOX expression in transfected 293T cell line by SUOX polyclonal antibody. Lane 1: SUOX transfected lysate (53.9kD). Lane 2: Non-transfected lysate.)

Immunoprecipitation (IP)

(Immunoprecipitation of SUOX transfected lysate using SUOX rabbit polyclonal antibody and Protein A Magnetic Bead and immunoblotted with SUOX purified mouse polyclonal antibody.)

Related Product Information for anti-SUOX antibody

Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins.

Product Categories/Family for anti-SUOX antibody

Antibodies; Abs to Enzymes; Oxidase

NCBI and Uniprot Product Information

• NCBI GI #: 74099704
• NCBI GeneID: 6821
• NCBI Accession #: NP_001027559.1
• NCBI GenBank Nucleotide #: NM_001032387.1
• UniProt Accession #: P51687
• Molecular Weight: 60,283 Da
• NCBI Official Full Name: sulfite oxidase, mitochondrial
• NCBI Official Synonym Full Names: sulfite oxidase
• NCBI Official Symbol: SUOX
• NCBI Protein Information: sulfite oxidase, mitochondrial
• UniProt Protein Name: Sulfite oxidase, mitochondrial
• Protein Family: Sulfite oxidase
• UniProt Gene Name: SUOX
• UniProt Entry Name: SUOX_HUMAN

NCBI Description

Sulfite oxidase is a homodimeric protein localized to the intermembrane space of mitochondria. Each subunit contains a heme domain and a molybdopterin-binding domain. The enzyme catalyzes the oxidation of sulfite to sulfate, the final reaction in the oxidative degradation of the sulfur amino acids cysteine and methionine. Sulfite oxidase deficiency results in neurological abnormalities which are often fatal at an early age. Alternative splicing results in multiple transcript variants encoding identical proteins. [provided by RefSeq, Jul 2008]

Uniprot Description

Catalytic activity: Sulfite + O2 + H2O = sulfate + H2O2.

Cofactor: Binds 1 heme B (iron-protoporphyrin IX) group non-covalently per subunit. Ref.4Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit

By similarity. Ref.4

Pathway: Energy metabolism; sulfur metabolism.

Subunit structure: Homodimer

By similarity.

Subcellular location: Mitochondrion intermembrane space.

Involvement in disease: Isolated sulfite oxidase deficiency (ISOD) [MIM:272300]: Characterized by neurological abnormalities including multicystic leukoencephalopathy with brain atrophy. Patients often suffer from seizures. Often leads to death at an early age.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9

Sequence similarities: Contains 1 cytochrome b5 heme-binding domain.

Sequence caution: The sequence AAA74886.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAL08048.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.