Transferrin Receptor, soluble Protein | TFRC protein

Transferrin Receptor, soluble (sTfr)

Cat. Num. AAA634782

• Gene Names: TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR
• Purity: >95%. (SDS-PAGE). Purified by immunoaffinity chromatography.
• Synonyms: Transferrin Receptor; soluble; soluble (sTfr); TFRC protein

• Host: Human blood
• Purity/Purification: >95%. (SDS-PAGE). Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a lyophilized powder from 10mM Tris-HCl, 0.15M sodium chloride, 5% mannitol, 0.1% CHAPS. No preservative added. Reconstitute with ddH2O.

• Preparation and Storage: Lyophilized powder may be stored at -20°C. Reconstitute with ddH2O. Store reconstituted material at 4°C. DO NOT FREEZE RECONSTITUTED PRODUCT. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for TFRC protein

Transferrin receptor is a 190kD Type II membrane glycoprotein which consists of two subunits of 95kD. It is expressed on activated lymphocytes, macrophages and monocytes. It binds Fe (Apo) transferrin. The gene coding for the antigen is located on the q-arm of chromosome 3. The ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias and lymphomas. Transferrin receptors are also present on reticulocytes, but are lost during maturation into erythrocytes.Transferrin receptor (CD71) has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer. The transferrin receptor has been structurally characterized as a disulfide-bound dimer of identical glycoprotein subunits of 95kDa. The transferrin receptor is not present on resting peripheral blood lymphocytes, but appears after mitogenic stimulation on B and T cells. Erythroblasts express high levels of CD71. It is also present on macrophages. It is expressed by some T-and B-cell lines. CD71 expression is linked to cell proliferation and intracellular iron concentration.

Product Categories/Family for TFRC protein

Molecular Biology; MB-Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 339516
• NCBI GeneID: 7037
• UniProt Accession #: P02786; Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0
• Molecular Weight: 84,871 Da
• NCBI Official Full Name: transferrin receptor
• NCBI Official Synonym Full Names: transferrin receptor
• NCBI Official Symbol: TFRC
• NCBI Official Synonym Symbols: T9; TR; TFR; p90; CD71; TFR1; TRFR
• NCBI Protein Information: transferrin receptor protein 1; transferrin receptor (p90, CD71)
• UniProt Protein Name: Transferrin receptor protein 1
• Protein Family: Transferrin receptor protein
• UniProt Gene Name: TFRC
• UniProt Synonym Gene Names: TR; TfR; TfR1; Trfr; sTfR
• UniProt Entry Name: TFR1_HUMAN

Uniprot Description

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; plasma membrane; melanosome; endosome; vesicle; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; positive regulation of bone resorption; transferrin transport; osteoclast differentiation; regulation of cell growth; transmembrane transport; regulation of cell proliferation