mGluR5,1a peptide(Metabotropic Glutamate Receptor) Peptide | Grm5 peptide

mGluR5,1a peptide(Metabotropic Glutamate Receptor)

Cat. Num. AAA633766

• Gene Names: Grm5; mGluR5; mGlur5
• Applications: Western Blot
• Purity: Purified; > 70%
• Synonyms: mGluR5; 1a peptide(Metabotropic Glutamate Receptor); Grm5 peptide

• Purity/Purification: Purified; > 70%
• Form/Format: Supplied as a lyophilized powder.

• Applicable Applications for Grm5 peptide: Western Blot (WB)
• Sequence (linear): C-Terminal 13 amino acids LIIRDYTQSSSSL of rat mGluR5, Metabotropic Glutamate Receptor 5. Corresponding antibody M3884-79B shows reactivity to mGluR1a with a species reactivity to human, rat, mouse and feline.; Metabotropic glutamate receptors have been classified into three groups. In general, class I receptors (mGluR1 and mGluR5) mediate the excitation of neurons, whereas activation of class II (mGluR2 and mGluR3) and class III (mGluR4a, mGluR7a, mGluR7b and mGluR8) results in a depression of synaptic transmission. Class I mGluRs are localized in the postsynaptic membrane and are positively coupled to phospholipase C (PLC). Class II and class III mGluRs localized to the presynaptic membrane and are negatively coupled to adenylate cyclase. It has been speculated that mGluR2 and/or mGluR3 may play a role in the modulation of the mossy terminal function.
• Preparation and Storage: Lyophilized powder may be stored at 4 degree C for short-term only. Stable for 12 months at -20 degree C. Reconstitute to nominal volume (see reconstitution instructions for peptides) and store at -20 degree C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Further dilutions can be made in assay buffer.

Product Categories/Family for Grm5 peptide

Molecular Biology; MB-Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 1170947
• NCBI GeneID: 24418
• UniProt Accession #: P31424
• Molecular Weight: 1483
• NCBI Official Full Name: Metabotropic glutamate receptor 5
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 5
• NCBI Official Symbol: Grm5
• NCBI Official Synonym Symbols: mGluR5; mGlur5
• NCBI Protein Information: metabotropic glutamate receptor 5; metabotropic glutamate receptor 5b; metabotropic glutamate receptor (mGluR5)
• UniProt Protein Name: Metabotropic glutamate receptor 5
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: Grm5
• UniProt Synonym Gene Names: Gprc1e; Mglur5; mGluR5
• UniProt Entry Name: GRM5_RAT

NCBI Description

may play a role in synaptic transmission; may interact with mGluR1, another group I metabotropic glutamate receptor [RGD, Feb 2006]

Uniprot Description

Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Ref.1

Subunit structure: Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3

By similarity. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1 and GRASP. Interacts with NCDN. Ref.3 Ref.4 Ref.5 Ref.7

Subcellular location: Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity: Widely distributed in neuronal cells of the central nervous system. Ref.1

Miscellaneous: Activated by quisqualate > glutamate > ibotenate > trans-1- aminocyclopentyl-1,3-dicarboxylate.

Sequence similarities: Belongs to the G-protein coupled receptor 3 family.