Mouse anti-Human PLXNB1 Monoclonal Antibody | anti-PLXNB1 antibody
PLXNB1 (Plexin B1, KIAA0407, MGC149167, PLXN5, Semaphorin Receptor SEP, SEP) (PE)
Gene Names
PLXNB1; SEP; PLXN5; KIAA0407; MGC149167; PLEXIN-B1
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
PLXNB1; Monoclonal Antibody; PLXNB1 (Plexin B1; KIAA0407; MGC149167; PLXN5; Semaphorin Receptor SEP; SEP) (PE); Anti -PLXNB1 (Plexin B1; anti-PLXNB1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10K24
Specificity
Recognizes human Plexin B1.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in saline, 0.5% BSA, 0.1% sodium azide. Labeled with R-Phycoerythrin (PE).
Applicable Applications for anti-PLXNB1 antibody
Flow Cytometry (FC/FACS)
Application Notes
Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 10ul labels 10e6 cells. Validated for use with Jurkat cells.
Dilution: Flow Cytometry: 10ul labels 10e6 cells. Validated for use with Jurkat cells.
Immunogen
NS0 cells transfected with aa1-2135 from isoform 1 of human PLXNB1 (O43157).
Hybridoma
Fusion of a mouse myeloma with B cells obtained from a mouse immunized with NS0 cells transfected with human PLXNB1.
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Stable for 12 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Related Product Information for anti-PLXNB1 antibody
PLXNB1 is a 300kD member of the B subfamily, plexin family of semaphorin receptors. Mature human PLXNB1 is a 2116aa type I transmembrane (TM) glycoprotein that contains a 1471aa extracellular domain (ECD) and a 612aa cytoplasmic region. The ECD contains one semaphorin domain, two PSI domains, and three IPT repeats. The ECD is cleaved into two subunits, a 200kD a-chain (aa20-1305) and a 100kD TM b-chain. The subunits are nondisulfide-linked and generate a high-affinity receptor. PLXNB1 is a receptor for CD100/Sema4D. It forms a receptor complex with neuropilins, MET, and EGFR2. Multiple splice variants are known. One shows a deletion of aa689-871. A second shows a 53aa substitution for aa677-2135. And a third shows a 53aa substitution for the 53aa between aa677-729. Over aa35-150, human PLXNB1 is 90% and 97% aa identical to dog and mouse PLXNB1, respectively.
Product Categories/Family for anti-PLXNB1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
232,298 Da
NCBI Official Full Name
plexin-B1
NCBI Official Synonym Full Names
plexin B1
NCBI Official Symbol
PLXNB1
NCBI Official Synonym Symbols
SEP; PLXN5; KIAA0407; MGC149167; PLEXIN-B1
NCBI Protein Information
plexin-B1; plexin 5; OTTHUMP00000164806; OTTHUMP00000210032; OTTHUMP00000210033; semaphorin receptor SEP
UniProt Protein Name
Plexin-B1
Protein Family
UniProt Gene Name
PLXNB1
UniProt Synonym Gene Names
KIAA0407; PLXN5; SEP
UniProt Entry Name
PLXB1_HUMAN
Uniprot Description
PLXNB1: Receptor for SEMA4D. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Belongs to the plexin family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; intracellular
Molecular Function: protein binding; transmembrane receptor activity; semaphorin receptor activity; GTPase activating protein binding; receptor activity; semaphorin receptor binding
Biological Process: positive regulation of phosphoinositide 3-kinase cascade; regulation of cell shape; axon guidance; cell migration; positive regulation of axonogenesis; negative regulation of osteoblast proliferation; negative regulation of cell adhesion; signal transduction; neurite morphogenesis; regulation of cytoskeleton organization and biogenesis
Research Articles on PLXNB1
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Product Notes
The PLXNB1 plxnb1 (Catalog #AAA633618) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The PLXNB1 (Plexin B1, KIAA0407, MGC149167, PLXN5, Semaphorin Receptor SEP, SEP) (PE) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's PLXNB1 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry. Dilution: Flow Cytometry: 10ul labels 10e6 cells. Validated for use with Jurkat cells. Researchers should empirically determine the suitability of the PLXNB1 plxnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PLXNB1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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