Mouse Mannose 6 Phosphate Receptor, Cation-independent Monoclonal Antibody | anti-IGF2R antibody

Mannose 6 Phosphate Receptor, Cation-independent (MPR, 300kD Mannose 6 Phosphate Receptor, Cation Independent Mannose 6 Phosphate Receptor, CI Man-6-P Receptor, CI-MPR, CIMPR, CD222, Insulin-like Growth Factor 2 Receptor, IGF2 Receptor, IGF2R, Insulin-lik

Cat. Num. AAA633028

• Gene Names: IGF2R; MPR1; MPRI; CD222; CIMPR; M6P-R
• Reactivity: Bovine, Human
• Applications: Western Blot, Immunoprecipitation, Immunofluorescence
• Purity: Purified; Purified
• Synonyms: Mannose 6 Phosphate Receptor; Cation-independent; Monoclonal Antibody; Cation-independent (MPR; 300kD Mannose 6 Phosphate Receptor; Cation Independent Mannose 6 Phosphate Receptor; CI Man-6-P Receptor; CI-MPR; CIMPR; CD222; Insulin-like Growth Factor 2 Receptor; IGF2 Receptor; IGF2R; Insulin-lik; Anti -Mannose 6 Phosphate Receptor; anti-IGF2R antibody

• Host: Mouse
• Reactivity: Bovine, Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 8L641
• Specificity: Species Crossreactivity: Crossreacts with Human, bovine and Non Human Primates.
• Purity/Purification: Purified; Purified
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.05% sodium azide.

• Applicable Applications for anti-IGF2R antibody: Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
• Application Notes: Suitable for use in Immunofluorescence, Western Blot and Immunoprecipitation.
• Immunogen: Purified bovine 300 kDa CI-MPR. Epitope: This antibody is shown to recognize an epitope in the extracellular domain of MPR.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-IGF2R antibody

Lysosomal enzymes containing one or two mannose 6-phosphate (man6P) moieties are moved about in the cell by two distinct but interconnected cycles by means of 300kD cation independent mannose 6-phospate receptors (CI-MPR). The biosynthetic cycle refers to the MPR transport of newly synthesized lysosomal enzymes from the trans Golgi network to late endosomes or early lysosomes. The endocytic cycle transports extracellular lysosomal enzymes from the plasma membrane via clathrin-coated vesicles to early endosomes. The entire pool of MPRs cycles between these cellular compartments every 3 hours. The steady state distribution of MPR's is predominantly within late endosomes, fewer in the trans Golgi network and ~10 % at cell surface.

Product Categories/Family for anti-IGF2R antibody

Antibodies; Abs to Golgi Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 188672
• NCBI GeneID: 3482
• UniProt Accession #: P11717; Q7Z7G9; Q96PT5; Q59EZ3
• Molecular Weight: 274,375 Da
• NCBI Official Full Name: mannose 6-phosphate receptor
• NCBI Official Synonym Full Names: insulin-like growth factor 2 receptor
• NCBI Official Symbol: IGF2R
• NCBI Official Synonym Symbols: MPR1; MPRI; CD222; CIMPR; M6P-R
• NCBI Protein Information: cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; OTTHUMP00000017536; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor
• UniProt Protein Name: Cation-independent mannose-6-phosphate receptor
• Protein Family: Cation-independent mannose-6-phosphate receptor
• UniProt Gene Name: IGF2R
• UniProt Synonym Gene Names: MPRI
• UniProt Entry Name: MPRI_HUMAN

NCBI Description

The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele. [provided by RefSeq]

Uniprot Description

IGF2R: a multifunctional type I transmembrane protein receptor that binds insulin-like growth factor 2 at the cell surface and mannose-6-phosphate-tagged proteins in the trans-Golgi network. Also known as the cation-independent mannose-6 phosphate (M6P) receptor. Clears IGF2 from the cell surface to attenuate signaling, and transports M6P-tagged lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. M6P-tagged lysosomal enzymes bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Belongs to the MRL1/IGF2R family.

Protein type: Receptor, misc.; Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 6q26

Cellular Component: extracellular space; focal adhesion; cell surface; clathrin coat; lysosomal membrane; integral to plasma membrane; trans-Golgi network; trans-Golgi network transport vesicle; membrane; endocytic vesicle; nuclear envelope lumen; perinuclear region of cytoplasm; late endosome; endosome

Molecular Function: G-protein coupled receptor activity; mannose binding; identical protein binding; protein binding; enzyme binding; retinoic acid binding; transporter activity; G-protein alpha-subunit binding; phosphoprotein binding; receptor activity; glycoprotein binding; insulin-like growth factor II binding; insulin-like growth factor receptor activity

Biological Process: receptor-mediated endocytosis; G-protein coupled receptor protein signaling pathway; organ regeneration; response to retinoic acid; insulin-like growth factor receptor signaling pathway; positive regulation of apoptosis; spermatogenesis; signal transduction; liver development; post-embryonic development

Disease: Hepatocellular Carcinoma