Western Blot (WB)
(All lanes : Anti-NRL Antibody at 1:1000 dilutionLane 1: 293T whole cell lysatesLane 2: PC-12 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 26 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Rabbit NRL Polyclonal Antibody | anti-NRL antibody
NRL Antibody
Western Blot (WB)
(All lanes : Anti-NRL Antibody at 1:1000 dilutionLane 1: 293T whole cell lysatesLane 2: PC-12 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 26 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Western Blot (WB)
(All lanes : Anti-NRL Antibody at 1:1000 dilutionLane 1: 293T whole cell lysatesLane 2: PC-12 whole cell lysatesLysates/proteins at 20 ug per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilutionPredicted band size : 26 kDaBlocking/Dilution buffer: 5% NFDM/TBST.)
Jackson A.U.,et al.Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
Farjo Q.,et al.Genomics 45:395-401(1997).
Li W.B.,et al.Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoceptor development and function. Mutations in this gene have been associated with retinitis pigmentosa and retinal degenerative diseases. [provided by RefSeq, Jul 2008]
Uniprot Description
NRL: Transcription factor which regulates the expression of several rod-specific genes, in cluding RHO and PDE6B. Defects in NRL are the cause of retinitis pigmentosa type 27 (RP27). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP27 inheritance is autosomal dominant. Defects in NRL are a cause of retinal degeneration autosomal recessive clumped pigment type (RDCP). A retinopathy characterized by night blindness since early childhood, consistent with a severe reduction in rod function. Color vision is normal although there is a relatively enhanced function of short-wavelength-sensitive cones in the macula. Signs of retinal degeneration and clusters of clumped pigment deposits in the peripheral fundus at the level of the retinal pigment epithelium are present (clumped pigmentary retinal degeneration). Belongs to the bZIP family.
Protein type: Transcription factor; DNA-binding
Chromosomal Location of Human Ortholog: 14q11.1-q11.2
Cellular Component: nucleus
Molecular Function: protein binding; leucine zipper domain binding; DNA binding
Biological Process: transcription from RNA polymerase II promoter; retinal rod cell development; visual perception; positive regulation of rhodopsin gene expression; response to stimulus; positive regulation of transcription from RNA polymerase II promoter; regulation of rhodopsin gene expression
Disease: Retinitis Pigmentosa 27
Research Articles on NRL
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Product Notes
The NRL nrl (Catalog #AAA9204587) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 11-70. The NRL Antibody reacts with Human, mouse, rat and may cross-react with other species as described in the data sheet. AAA Biotech's NRL can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~ 1:1000. Researchers should empirically determine the suitability of the NRL nrl for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NRL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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