Rabbit anti-Human, Mouse hCG_1745121 Polyclonal Antibody | anti-hCG_1745121 antibody

hCG_1745121, CT (ISPD, Isoprenoid synthase domain-containing protein, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (FITC)

Cat. Num. AAA6305738

• Gene Names: ISPD; Nip; MDDGA7; MDDGC7; hCG_1745121
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: hCG_1745121; Polyclonal Antibody; CT (ISPD; Isoprenoid synthase domain-containing protein; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein) (FITC); ISPD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein; anti-hCG_1745121 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-hCG_1745121 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: hCG_1745121 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-437 amino acids from the C-terminal region of human hCG_1745121.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(hCG_1745121 Antibody (C-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the CG_1745121 antibody detected CG_1745121 protein (arrow).)

Product Categories/Family for anti-hCG_1745121 antibody

Antibodies; Enzymes; Synthase

NCBI and Uniprot Product Information

• NCBI GI #: 157412259
• NCBI GeneID: 729920
• NCBI Accession #: NP_001094896.1
• NCBI GenBank Nucleotide #: NM_001101426.3
• UniProt Accession #: A4D126; A8MU35; H9KVB2
• Molecular Weight: 44,389 Da
• NCBI Official Full Name: isoprenoid synthase domain-containing protein isoform a
• NCBI Official Synonym Full Names: isoprenoid synthase domain containing
• NCBI Official Symbol: ISPD
• NCBI Official Synonym Symbols: Nip; MDDGA7; MDDGC7; hCG_1745121
• NCBI Protein Information: isoprenoid synthase domain-containing protein
• UniProt Protein Name: D-ribitol-5-phosphate cytidylyltransferase
• UniProt Gene Name: ISPD
• UniProt Synonym Gene Names: hISPD

NCBI Description

This gene encodes a 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein. Mutations in this gene are the cause of Walker-Warburg syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Uniprot Description

Cytidylyltransferase required for protein O-linked mannosylation (PubMed:26687144, PubMed:27130732, PubMed:27601598, PubMed:22522420, PubMed:22522421). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate (PubMed:26687144, PubMed:27130732). CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (PubMed:26687144, PubMed:27130732). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (PubMed:26687144). Not Involved in dolichol production (PubMed:26687144).