Rabbit anti-Human, Mouse hCG_1745121 Polyclonal Antibody

hCG_1745121, CT (ISPD, Isoprenoid synthase domain-containing protein, 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein)

Cat. Num. AAA642714

• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by Protein A affinity chromatography.
• Synonyms: hCG_1745121; Polyclonal Antibody; CT (ISPD; Isoprenoid synthase domain-containing protein; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein); Anti -hCG_1745121; anti-hCG_1745121 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human, mouse
• Purity/Purification: Affinity Purified; Purified by Protein A affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

• Applicable Applications for anti-hCG_1745121 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA; Dilution: ELISA: 1:1,000; Western Blot: 1:100-500
• Immunogen: hCG_1745121 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 407-437 amino acids from the C-terminal region of human hCG_1745121.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(hCG_1745121 Antibody (C-term) western blot analysis in mouse heart tissue lysates (15ug/lane).This demonstrates the CG_1745121 antibody detected CG_1745121 protein (arrow).)

Product Categories/Family for anti-hCG_1745121 antibody

Antibodies; Abs to Enzymes; Synthase

NCBI and Uniprot Product Information

• NCBI GI #: 119614074
• NCBI Official Full Name: hCG1745121

Uniprot Description

ISPD: Required for protein O-linked mannosylation. Probably acts as a nucleotidyltransferase involved in synthesis of a nucleotide sugar. Required for dystroglycan O-mannosylation. Defects in ISPD are the cause of muscular dystrophy- dystroglycanopathy congenital with brain and eye anomalies type A7 (MDDGA7). MDDGA7 is an autosomal recessive disorder characterized by congenital muscular dystrophy associated with cobblestone lissencephaly and other brain anomalies, eye malformations, profound mental retardation, and death usually in the first years of life. Included diseases are the more severe Walker-Warburg syndrome and the slightly less severe muscle-eye- brain disease. Belongs to the IspD family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.7.-; Transferase

Chromosomal Location of Human Ortholog: 7p21.2

Molecular Function: nucleotidyltransferase activity

Biological Process: axon guidance; isoprenoid biosynthetic process; protein amino acid O-linked mannosylation

Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 7; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 7