Rabbit anti-Human HAUS7 Polyclonal Antibody | anti-HAUS7 antibody

HAUS7, NT (HAUS7, UCHL5IP, UIP1, HAUS augmin-like complex subunit 7, 26S proteasome-associated UCH37-interacting protein 1, UCHL5-interacting protein, X-linked protein STS1769) (Biotin)

Cat. Num. AAA6305517

• Gene Names: HAUS7; UIP1; UCHL5IP
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: HAUS7; Polyclonal Antibody; NT (HAUS7; UCHL5IP; UIP1; HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769) (Biotin); X-linked protein STS1769; anti-HAUS7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-HAUS7 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: HAUS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 3-33 amino acids from the N-terminal region of human HAUS7.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(HAUS7 Antibody (N-term) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the HAUS7 antibody detected the HAUS7 protein (arrow).)

Related Product Information for anti-HAUS7 antibody

This gene encodes a protein identified by interaction with ubiquitin C-terminal hydrolase 37, which functions to edit polyubiquitin chains on ubiquitinated substrates. This protein is a subunit of the multisubunit augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis.

Product Categories/Family for anti-HAUS7 antibody

Antibodies; Proteasomes

References

Xin, X., et al. Genome Res. 19(7):1262-1269(2009). Lawo, S., et al. Curr. Biol. 19(10):816-826(2009). Uehara, R., et al. Proc. Natl. Acad. Sci. U.S.A. 106(17):6998-7003(2009). Chen, M.J., et al. Nucleic Acids Res. 35(8):2682-2694(2007). Hahn, Y., et al. Hum. Genet. 119 (1-2), 169-178 (2006).

NCBI and Uniprot Product Information

• NCBI GI #: 66346717
• NCBI GeneID: 55559
• NCBI Accession #: NP_059988.3
• NCBI GenBank Nucleotide #: NM_017518.7
• UniProt Accession #: Q99871; Q96HS8; Q9NP54; Q9UFH9; B4DUH6; D3DWT9
• Molecular Weight: 37,524 Da
• NCBI Official Full Name: HAUS augmin-like complex subunit 7
• NCBI Official Synonym Full Names: HAUS augmin-like complex, subunit 7
• NCBI Official Symbol: HAUS7
• NCBI Official Synonym Symbols: UIP1; UCHL5IP
• NCBI Protein Information: HAUS augmin-like complex subunit 7
• UniProt Protein Name: HAUS augmin-like complex subunit 7
• Protein Family: HAUS augmin-like complex
• UniProt Gene Name: HAUS7
• UniProt Synonym Gene Names: UCHL5IP; UIP1
• UniProt Entry Name: HAUS7_HUMAN

NCBI Description

This gene encodes a subunit of the augmin complex, which regulates centrosome and mitotic spindle integrity, and is necessary for the completion of cytokinesis. The encoded protein was identified by interaction with ubiquitin C-terminal hydrolase 37. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]

Uniprot Description

HAUS7: Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. Belongs to the HAUS7 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Deoxyribonuclease; EC 3.1.11.2

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: microtubule; centrosome; cytoplasm; plasma membrane; nucleolus; spindle

Molecular Function: thioesterase binding

Biological Process: mitosis; cell division; centrosome organization and biogenesis; spindle assembly