Goat anti-Human Complement C4 Polyclonal Antibody | anti-C4b antibody
Complement C4, Human
Gene Names
C4b; C4; C4a; C4-1
Reactivity
Human
Applications
ELISA
Purity
Serum
Synonyms
Complement C4; Polyclonal Antibody; Human; Anti -Complement C4; anti-C4b antibody
Host
Goat
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human complement component C4 (pooled normal human plasma and pooled 2X concentrated human serum) by immunoelectrophoresis
Purity/Purification
Serum
Form/Format
Supplied as a liquid in TBS, pH 7.5, 0.01% sodium azide
Applicable Applications for anti-C4b antibody
Suitable for use in ELISA. Other applications not tested
Optimal dilutions to be determined by the researcher.
Optimal dilutions to be determined by the researcher.
Application Notes
Suitable for use in ELISA.
Immunogen
Purified human C4 protein
Type
PAB
Grade
Serum
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-C4b antibody
C4 consists of three polypeptide chains (alpha, molecular weight 95kD, beta, molecular weight 75kD and gamma, molecular weight 33kD) and is usually present in serum at 200-600mg/L. It is a protein of the classical complement pathway. When activated by C1s, a peptide C4a is released and the generated C4b binds C2 which is in turn cleaved by C1s to produce the classical pathway C3 convertase, namely C4b2a. C4b also has opsonin activity and binds to macrophages and neutrophils via their CR1 receptor.
Product Categories/Family for anti-C4b antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
192,163 Da
NCBI Official Full Name
complement C4
NCBI Official Synonym Full Names
complement component 4B (Chido blood group)
NCBI Official Symbol
C4b
NCBI Official Synonym Symbols
C4; C4a; C4-1
NCBI Protein Information
complement C4; complement component 4a; complement component 4, gene 1; complement component 4 (within H-2S); complement component 4B (Childo blood group)
UniProt Protein Name
Complement C4
Protein Family
UniProt Gene Name
C4
UniProt Synonym Gene Names
C4a
UniProt Entry Name
CO4_RAT
NCBI Description
complement protein, part of the classical activation pathway; localizes to the class III region of the MHC [RGD]
Uniprot Description
C4A: Derived from proteolytic degradation of complement C4, C4a anaphylatoxin is a mediator of local inflammatory processes. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes
Protein type: Secreted, signal peptide; Inhibitor; Secreted
Cellular Component: extracellular space; extracellular region
Molecular Function: complement component C1q binding; endopeptidase inhibitor activity
Biological Process: innate immune response; inflammatory response; complement activation, classical pathway; complement activation
Research Articles on C4b
Similar Products
Product Notes
The C4b c4 (Catalog #AAA626457) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Complement C4, Human reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Complement C4 can be used in a range of immunoassay formats including, but not limited to, Suitable for use in ELISA. Other applications not tested Optimal dilutions to be determined by the researcher. Suitable for use in ELISA. Researchers should empirically determine the suitability of the C4b c4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Complement C4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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