Related Product Information for anti-PPM1G antibody
Cell cycle progression is regulated by cyclins and their cognate Cdks. p21 (WAF1/CIP1) inhibits the activity of each member of the cyclin/Cdk family, and overexpression of this protein inhibits the proliferation of mammalian cells. The expression of p21 is inducible by a wide range of stress stimuli. p21 is tightly regulated at the transcriptional level by p53, and probably serves as the effector of p53 cell cycle control.
Product Categories/Family for anti-PPM1G antibody
NCBI Description
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Uniprot Description
PPM1G: is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Protein type: Motility/polarity/chemotaxis; Spliceosome; Protein phosphatase, Ser/Thr (non-receptor); EC 3.1.3.16
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: nucleoplasm; cytoplasm; nucleus
Molecular Function: protein binding; metal ion binding; protein serine/threonine phosphatase activity
Biological Process: protein amino acid dephosphorylation; cell cycle arrest
Product Notes
The PPM1G ppm1g (Catalog #
AAA626296) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The p21Cip1/WAF1 Phosphorylated (Thr145) (Cyclin-dependent Kinase Inhibitor 1, CDK-interacting Protein 1, Melanoma Differentiation-associated Protein 6, MDA-6, p21, CDKN1A, CAP20, CDKN1, CIP1, MDA6, PIC1, SDI1, WAF1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's p21Cip1/WAF1 Phosphorylated can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry. Dilution: Immunohistochemistry:1:50-1:100. Researchers should empirically determine the suitability of the PPM1G ppm1g for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process.
It is sometimes possible for the material contained within the vial of
"p21Cip1/WAF1 Phosphorylated, Polyclonal Antibody" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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All products in the AAA Biotech catalog are strictly for research-use only, and are
absolutely not suitable for use in any
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product from AAA Biotech, you
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industry standard. AAA Biotech
and its authorized distribution partners reserve the right to refuse to fulfill any order if
we have any indication that a
purchaser may be intending to use a product outside of our accepted criteria.
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