Mouse anti-Human CD62E Monoclonal Antibody | anti-CD62E antibody
CD62E (LECAM, E-Selectin, ELAM1, Endothelial Leukocyte Adhesion Molecule) (MaxLight 405)
Reactivity
Human
Applications
Flow Cytometry, Functional Assay, Immunocytochemistry, Immunohistochemistry
Purity
~95% (SDS gel electrophoresis)
Synonyms
CD62E; Monoclonal Antibody; CD62E (LECAM; E-Selectin; ELAM1; Endothelial Leukocyte Adhesion Molecule) (MaxLight 405); anti-CD62E antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
5J85
Specificity
Recognizes human CD62E. Species Crossreactivity: Canine L-selectin but not with canine E-selectin. Does not cross-react with mouse.
Purity/Purification
~95% (SDS gel electrophoresis)
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with MaxLight405.
Applicable Applications for anti-CD62E antibody
Flow Cytometry (FC/FACS), FLISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC)
Immunogen
Human CD62E
Conjugate
MaxLight405
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Product Categories/Family for anti-CD62E antibody
References
1. Abbassi, O., T.K. Kishimoto, L.V. McIntire, D.C. Anderson, and C.W. Smith (1993) E-selectin supports neutrophil rolling in vitro under conditions of flow. J. Clin. Invest. 92:2719-2730. 2. Brandley, B.K., S.J. Swiedler, and P.W. Robbins (1990) Carbohydrate ligands of the LEC cell adhesion molecules. Cell 63:861-863. 3. Giese, M.J., D.C. Shum, S.A. Rayner, B.J. Mondino, and J.A. Berliner (2000) Adhesion molecule expression in a rat model of Staphylococcus aureus endophthalmitis. Invest. Ophthal. Vis. Sci. 41:145- 153. 4. Hogg, N. (1992) Roll, roll, roll your leucocyte gently down the vein.. Immunol. Today 13:113-115. 5. Kishimoto, T.K., R.A Warnock, M.A. Jutila, E.C. Butcher, C. Lane, D.C. Anderson, and C.W. Smith (1991) Antibodies against human neutrophil LECAM-1 (LAM-1/Leu-8/DREG-56 antigen) and endothelial cell AM-1 inhibit a common CD18-independent adhesion pathway in vitro. Blood 78:805-811. 6. Kyan-Aung, U., D.O. Haskard, R.N. Poston, M.H. Thornhill, and T.H. Lee (1991) Endothelial leukocyte adhesion molecule-1 and intercellular adhesion molecule-1 mediate the adhesion of eosinophils to endothelial cells in vitro and are expressed by endothelium in allergic cutaneous inflammation in vivo. J. Immunol. 146:521-528. 7. Luscininskas, F.W., M.I. Cybulsky, J.-M. Kiely, C.S. Peckins, V.M. Davis, and M.A. Gimbrone (1991) Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both endothelial-leukocyte adhesion molecule-1 and intercellular adhesion molecule- 1. J. Immunol. 146:1617-1625. 8. Mulligan, M.S., J. Vasrani, M.K. Dame, C.L. Lane, C.W. Smith, D.C. Anderson, and P.A. Ward (1991) Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J. Clin. Invest. 88:1396-1406. 9. Munro, J.M., J.S. Pober, and R.S. Cotran (1991) Recruitment of neutrophils in the local endotoxin response: association with de novo endothelial expression of endothelial leukocyte adhesion molecule-1. Lab. Invest. 64: 295-299. 10. Parekh, R.B. and C.J. Edge (1994) Selectins--glycoprotein targets for therapeutic intervention in inflammation. Trends Biotechnol. 12(9):339-345. 11. Peichev, M., A.J. Naiyer, D. Pereira, Z.P. Zhu, W.J. Lane, M. Williams, C. Oz, D.J. Hicklin, L. Witte, M.A.S. Moore, and S. Rafii (2000) Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood 95:952-958. 12. Picker, L.J., T.K. Kishimoto, C.W. Smith, R.A. Warnock, and E.C. Butcher (1991) ELAM-1 is an adhesion molecule for skin-homing T cells. Nature 349:796-799. 13. Shimizu, Y., S. Shaw, N. Graber, T.V. Gopal, K.J. Horgan, G.A. Van Seventer, and W. Newman (1991) Activation-independent binding of human memory T cells to adhesion molecule ELAM-1. Nature 349:799- 802. 14. Springer, T.A., and L.A. Lasky (1991) Cell adhesion. Sticky sugars for selectins. Nature 349:196-197. Zhang, Y. and S. Neelamegham (2002) Estimating the efficiency of cell capture and arrest in flow chambers: Study of neutrophil binding via E-selectin and ICAM-1. Biophys. J. 83(4):1934-1952. 15. Zimmerman, G.A., S.M. Prescott, and T.M. McIntyre (1992) Endothelial cell interactions with granulocytes: tethering and signaling molecules. Immunol. Today 12:93-100.
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Product Notes
The CD62E (Catalog #AAA6259276) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD62E (LECAM, E-Selectin, ELAM1, Endothelial Leukocyte Adhesion Molecule) (MaxLight 405) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD62E can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS), FLISA, Immunocytochemistry (ICC), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the CD62E for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD62E, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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