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Rat anti-Mouse CD137 Monoclonal Antibody | anti-CD137 antibody

CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor Superfamily member 9 precursor) (MaxLight 550)

Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Purity
Purified by Protein G Affinity Chromatography
Synonyms
CD137; Monoclonal Antibody; CD137 (4-1BB; TNFRSF9; 4-1BB ligand receptor; CD137 antigen; CDw137; ILA; MGC2172; T-cell antigen 4-1BB homolog; T-cell antigen ILA; Tumor necrosis factor receptor Superfamily member 9 precursor) (MaxLight 550); anti-CD137 antibody
Ordering
For Research Use Only!
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
3H1858
Specificity
Recognizes mouse CD137 (the mouse homologue of human 4-1BB protein).
Purity/Purification
Purified by Protein G Affinity Chromatography
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight550.
Applicable Applications for anti-CD137 antibody
Flow Cytometry (FC/FACS)
Immunogen
Murine CD137 human Fc fusion protein.
Conjugate
MaxLight550
Preparation and Storage
Store at 4 degree C. Do Not Freeze.
Product Categories/Family for anti-CD137 antibody
References
1. Chu NR; DeBenedette MA; Stiernholm BJ; Barber BH; Watts TH. Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28-T cells. Journal of Immunology, 1997, 158:3081-9. 2. DeBenedette MA; Shahinian A; Mak TW; Watts TH. Costimulation of CD28-T lymphocytes by 4-1BB ligand. Journal of Immunol, 1997, 158:551-9. 3. Hurtado JC; Kim YJ; Kwon BS. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death. Journal of Immunology, 1997, 158(6):2600-9. 4. Loo DT; Chalupny NJ; Bajorath J; Shuford WW; Mittler RS; Aruffo A. Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB. Journal of Biological Chemistry, 1997 Mar 7, 272(10):6448-56. 5. Garni-Wagner BA; Lee ZH; Kim YJ; Wilde C; Kang CY; Kwon BS. 4-1BB is expressed on CD45RAhiROhi transitional T cell in humans. Cellular Immunology, 1996, 169(1):91-8. 6. Gruss HJ; Duyster J; Herrmann F. Structural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin's disease. Annals of Oncology, 1996, 7 Suppl 4:19-26. 7. Schwarz H; Blanco FJ; von Kempis J; Valbracht J; Lotz M. ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival. Blood, 1996, 87(7):2839-45. 8. Birkeland ML; Copeland NG; Gilbert DJ; Jenkins NA; Barclay AN. Gene structure and chromosomal localization of the mouse homologue of rat OX40 protein. European Journal of Immunology, 1995, 25(4):926-30. 9. DeBenedette MA; Chu NR; Pollok KE; Hurtado J; Wade WF; Kwon BS; Watts TH. Role of 4-1BB ligand in costimulation of T lymphocyte growth and its upregulation on M12 B lymphomas by cAMP. Journal of Experimental Med, 1995, 181:985-92. 10. Gruss HJ; Dower SK. Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood, 1995, 85:3378-404. 11. Hurtado JC; Kim SH; Pollok KE; Lee ZH; Kwon BS. Potential role of 4-1BB in T cell activation. Comparison with the costimulatory molecule CD28. Journal of Immunology, 1995 Oct 1, 155(7):3360-7. 12. Katsikis PD; Wunderlich ES; Smith CA; Herzenberg LA; Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. Journal of Experimental Medicine, 1995 Jun 1, 181(6):2029-36. 13. Pollok KE; Kim SH; Kwon BS. Regulation of 4-1BB expression by cell-cell interactions and the cytokines, interleukin-2 and interleukin-4. European Journal of Immunology, 1995 Feb, 25(2):488-94. 14. Schwarz H; Valbracht J; Tuckwell J; von Kempis J; Lotz M. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood, 1995 Feb 15, 85(4):1043-52. 15. Setareh M; Schwarz H; Lotz M. A mRNA variant encoding a soluble form of 4-1BB, a member of the murine NGF/TNF receptor family. Gene, 1995, 164(2):311-5. 16. Wu Y; Xu J; Shinde S; Grewal I; Henderson T; Flavell RA; Liu Y. Rapid induction of a novel costimulatory activity on B cells by CD40 ligand. Current Biology, 1995, 5(11):1303-11. 17. Zhou Z; Kim S; Hurtado J; Lee ZH; Kim KK; Pollok KE; Kwon BS. Characterization of human homologue of 4-1BB and its ligand. Immunology Letters, 1995, 45(1-2):67-73. 18. Alderson MR. Regulation of immune responses by the ligands for CD27, CD30, and 4-1BB. Circulatory Shock, 1994, 44(2):73-6. 19. Alderson MR; Smith CA; Tough TW; Davis-Smith T; Armitage RJ; Falk B; Roux E; Baker E; Sutherland GR; Din WS; et al. Molecular and biological characterization of human 4-1BB and its ligand. European Journal of Immunology, 1994, 24(9):2219-27. 20. Kwon BS; Kozak CA; Kim KK; Pickard RT. Genomic organization and chromosomal localization of the T-cell antigen 4-1BB. Journal of Immunology, 1994, 152(5):2256-62. 21. Myers SM; Ross GM; Dostaler SM; Anderson MN; Weaver DF; Riopelle RJ. Putative cytoplasmic amphiphilic domains in the nerve growth factor/tumour necrosis factor receptor superfamily. Biochim Biophys Acta, 1994, 1196(1):21-8. 22. Pollok KE; Kim YJ; Hurtado J; Zhou Z; Kim KK; Kwon BS. 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. European Journal of Immunology, 1994, 24(2):367-74. 23. Zhou Z; Pollok KE; Kim KK; Kim YJ; Kwon BS. Functional analysis of T-cell antigen 4-1BB in activated intestinal intra-epithelial T lymphocytes. Immunology Letters, 1994, 41(2-3):177-84. 24. Goodwin RG; Din WS; Davis-Smith T; Anderson DM; Gimpel SD; Sato TA; Maliszewski CR; Brannan CI; Copeland NG; Jenkins NA; et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. European Journal of Immunology, 1993, 23:2631-41. 25. Gravestein LA; Blom B; Nolten LA; de Vries E; van der Horst G; Ossendorp F; Borst J; Loenen WA. Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. European Journal of Immunology, 1993, 23(4):943-50. 26. Kim YJ; Pollok KE; Zhou Z; Shaw A; Bohlen JB; Fraser M; Kwon BS. Novel T cell antigen 4-1BB associates with the protein tyrosine kinase p56lck1. Journal of Immunology, 1993, 151(3):1255-62. 27. Pollok KE; Kim YJ; Zhou Z; Hurtado J; Kim KK; Pickard RT; Kwon BS. Inducible T cell antigen 4-1BB. Analysis of expression and function. Journal of Immunology, 1993, 150(3):771-81. 28. Schwarz H; Tuckwell J; Lotz M. A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family. Gene, 1993, 134(2):295-8. 29. Chalupny NJ; Peach R; Hollenbaugh D; Ledbetter JA; Farr AG; Aruffo A. T-cell activation molecule 4-1BB binds to extracellular matrix proteins. Proceedings of the National Academy of Sciences of the United States of America, 1992, 89(21):10360-4. 30. Marsters SA; Frutkin AD; Simpson NJ; Fendly BM; Ashkenazi A. Identification of cysteine-rich domains of the type 1 tumor necrosis factor receptor involved in ligand binding. Journal of Biological Chemistry, 1992, 267(9):5747-50. 31. Camerini D; Walz G; Loenen WA; Borst J; Seed B. The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. Journal of Immunology, 1991, 147(9):3165-9.

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Product Notes

The CD137 (Catalog #AAA6254459) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The CD137 (4-1BB, TNFRSF9, 4-1BB ligand receptor, CD137, CD137 antigen, CDw137, ILA, MGC2172, T-cell antigen 4-1BB homolog, T-cell antigen ILA, Tumor necrosis factor receptor Superfamily member 9 precursor) (MaxLight 550) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD137 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CD137 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD137, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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