Goat AMPD1 Polyclonal Antibody | anti-AMPD1 antibody

AMPD1 (Adenosine Monophosphate Deaminase 1 (Isoform M), MAD, MADA, Adenosine Monophosphate Deaminase-1 (Muscle), OTTHUMP00000059283)

Cat. Num. AAA623210

• Gene Names: AMPD1; MAD; MADA
• Reactivity: Bovine, Canine, Human, Mouse, Porcine, Rat
• Applications: ELISA
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: AMPD1; Polyclonal Antibody; AMPD1 (Adenosine Monophosphate Deaminase 1 (Isoform M); MAD; MADA; Adenosine Monophosphate Deaminase-1 (Muscle); OTTHUMP00000059283); Anti -AMPD1 (Adenosine Monophosphate Deaminase 1 (Isoform M); anti-AMPD1 antibody

• Host: Goat
• Reactivity: Bovine, Canine, Human, Mouse, Porcine, Rat
• Clonality: Polyclonal
• Specificity: Recognizes AMPD1. Species Crossreactivity: Bovine, canine, mouse, porcine and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-AMPD1 antibody: ELISA (EL/EIA)
• Application Notes: Suitable for use in ELISA.; Dilution: ELISA: 1:1000
• Immunogen: Synthetic peptide of AMPD1.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-AMPD1 antibody

The AMPD1 gene provides instructions for producing an enzyme called adenosine monophosphate deaminase. This enzyme is found in the muscles used for movement (skeletal muscles), where it plays a role in the production of energy. Specifically, this enzyme converts a molecule called adenosine monophosphate (AMP) to a molecule called inosine monophosphate (IMP) as part of a process that produces energy within muscle cells.

At least eight mutations in the AMPD1 gene have been found to cause AMP deaminase deficiency. Most cases are caused by a mutation that results in a premature stop signal in the instructions for making AMP deaminase (written as Gly12Ter or Q12X). The resulting enzyme is abnormally short and cannot fulfill its role in the process of energy production in skeletal muscle cells. A lack of functional enzyme can cause muscles to tire easily during physical activity, leading to muscle weakness or pain in some people with AMP deaminase deficiency. Other people with mutations in this gene never experience any signs and symptoms associated with AMP deaminase deficiency.

Product Categories/Family for anti-AMPD1 antibody

Antibodies; Abs to Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 289547500
• NCBI GeneID: 270
• NCBI Accession #: NP_000027.2
• NCBI GenBank Nucleotide #: NM_000036.2
• UniProt Accession #: P23109; Q5TF00; Q5TF02; Q5W9V2; Q6F4B5; Q6F4B6; Q6F4B7; Q6F4B8; Q6F4B9; Q6I6Y1; Q6I6Y2
• Molecular Weight: 86,490 Da
• NCBI Official Full Name: AMP deaminase 1 isoform 1
• NCBI Official Synonym Full Names: adenosine monophosphate deaminase 1
• NCBI Official Symbol: AMPD1
• NCBI Official Synonym Symbols: MAD; MADA
• NCBI Protein Information: AMP deaminase 1; AMPD; OTTHUMP00000013665; OTTHUMP00000013666; skeletal muscle AMPD; myoadenylate deaminase; adenosine monophosphate deaminase-1 (muscle); adenosine monophosphate deaminase 1 (isoform M)
• UniProt Protein Name: AMP deaminase 1
• Protein Family: AMP deaminase
• UniProt Gene Name: AMPD1
• UniProt Entry Name: AMPD1_HUMAN

NCBI Description

Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.

Uniprot Description

AMPD1: AMP deaminase plays a critical role in energy metabolism. Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM). AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue. Belongs to the adenosine and AMP deaminases family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Hydrolase; EC 3.5.4.6; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: cytosol

Molecular Function: metal ion binding; AMP deaminase activity; myosin heavy chain binding

Biological Process: response to organic substance; IMP salvage; nucleobase, nucleoside and nucleotide metabolic process; purine salvage; purine base metabolic process

Disease: Myopathy Due To Myoadenylate Deaminase Deficiency