Western Blot (WB)
(Western Blot analysis of AMPD1 in Human fetal muscle tissue using AMPD1 Rabbit pAb at dilution 1/1600)
Rabbit anti-Human AMPD1 Polyclonal Antibody | anti-AMPD1 antibody
AMPD1 Rabbit pAb
IHC-P: 1:100-1:300
Western Blot (WB)
(Western Blot analysis of AMPD1 in Human fetal muscle tissue using AMPD1 Rabbit pAb at dilution 1/1600)
Western Blot (WB)
(Western Blot analysis of AMPD1 in Human fetal muscle tissue using AMPD1 Rabbit pAb at dilution 1/1600)
Immunohistochemistry (IHC)
(Immunohistochemistry of AMPD1 in paraffin-embedded Human liver cancer tissue using AMPD1 Rabbit pAb at dilution 1/70. Predicted cell location: Cytoplasm)
Immunohistochemistry (IHC)
(Immunohistochemistry of AMPD1 in paraffin-embedded Human liver cancer tissue using AMPD1 Rabbit pAb at dilution 1/70. Predicted cell location: Cytoplasm)
NCBI and Uniprot Product Information
NCBI Description
Adenosine monophosphate deaminase 1 catalyzes the deamination of AMP to IMP in skeletal muscle and plays an important role in the purine nucleotide cycle. Two other genes have been identified, AMPD2 and AMPD3, for the liver- and erythocyte-specific isoforms, respectively. Deficiency of the muscle-specific enzyme is apparently a common cause of exercise-induced myopathy and probably the most common cause of metabolic myopathy in the human. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
Uniprot Description
AMPD1: AMP deaminase plays a critical role in energy metabolism. Defects in AMPD1 are the cause of adenosine monophosphate deaminase deficiency muscle type (AMPDDM). AMPDDM is a metabolic disorder resulting in exercise-related myopathy. It is characterized by exercise-induced muscle aches, cramps, and early fatigue. Belongs to the adenosine and AMP deaminases family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - purine; EC 3.5.4.6; Hydrolase
Chromosomal Location of Human Ortholog: 1p13
Cellular Component: cytosol
Molecular Function: metal ion binding; AMP deaminase activity; myosin heavy chain binding
Biological Process: response to organic substance; IMP salvage; nucleobase, nucleoside and nucleotide metabolic process; purine salvage; purine base metabolic process
Disease: Myopathy Due To Myoadenylate Deaminase Deficiency
Research Articles on AMPD1
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Product Notes
The AMPD1 ampd1 (Catalog #AAA4759572) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AMPD1 Rabbit pAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AMPD1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry-Paraffin (IHC-P). WB: 1:500-1:2000 IHC-P: 1:100-1:300. Researchers should empirically determine the suitability of the AMPD1 ampd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AMPD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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