Goat anti-Human NEUREXIN 1 Polyclonal Antibody | anti-Nrxn1 antibody

NEUREXIN 1, CT (NRXN1, DKFZp313P2036, FLJ35941, Hs.22998, KIAA0578, Neurexin-1-alpha Precursor, Neurexin-1-beta Precursor, Neurexin I-alpha, Neurexin I-beta)

Cat. Num. AAA621303

• Gene Names: Nrxn1; Nrxn1b
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: NEUREXIN 1; Polyclonal Antibody; CT (NRXN1; DKFZp313P2036; FLJ35941; Hs.22998; KIAA0578; Neurexin-1-alpha Precursor; Neurexin-1-beta Precursor; Neurexin I-alpha; Neurexin I-beta); Anti -NEUREXIN 1; anti-Nrxn1 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes an epitope within the C-terminal region of human Neurexin 1 (NRXN1). Species sequence homology: mouse, rat, canine.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris-saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

• Applicable Applications for anti-Nrxn1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:32,000; Western Blot: 0.05-0.1ug/ml
• Immunogen: Peptide sequence C-KEKQPSSAKSSNKN from the C-Terminal region of NRXN1 (NP_004792.1; NP_620072.1).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-Nrxn1 antibody

Neurexin 1 (NRXN1), a transmembrane neuronal protein and member of the neurexin family, which act as cell adhesion molecules and receptors within the vertebrate nervous system. NRXN1 exists in many distinct isoforms, the majority of which encode the longer alpha-neurexins generated using an upstream promoter, whilst fewer encode the shorter beta-neurexins, generated using a downstream promoter. Alpha-neurexins have been shown to bind with high affinity to the neuronal protein neurexophilin, whilst neuroligin 1, enriched in synaptic plasma membranes, has been identified as a splice site-specific ligand for beta-neurexins.

Product Categories/Family for anti-Nrxn1 antibody

Antibodies; Abs to Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 37620151
• NCBI GeneID: 60391
• NCBI Accession #: NP_068535.2
• NCBI GenBank Nucleotide #: NM_021767.2
• UniProt Accession #: Q63372; Q63373
• Molecular Weight: 167,923 Da
• NCBI Official Full Name: neurexin 1
• NCBI Official Synonym Full Names: neurexin 1
• NCBI Official Symbol: Nrxn1
• NCBI Official Synonym Symbols: Nrxn1b
• NCBI Protein Information: neurexin 1; neurexin I-beta; neurexin-1-beta; neurexin I-alpha; neurexin-1-alpha; non-processed neurexin I-alpha
• UniProt Protein Name: Neurexin-1-alpha
• Protein Family: Neurexin
• UniProt Gene Name: Nrxn1
• UniProt Entry Name: NRX1A_RAT

NCBI Description

neuronal cell recognition molecule; may have a role in synaptogenesis [RGD]

Uniprot Description

NRXN1: Cell surface protein involved in cell-cell-interactions, excytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)- triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latroxin from spider venom. Belongs to the neurexin family. 4 isoforms of the human protein are produced by alternative promoter.

Protein type: Receptor, misc.; Membrane protein, integral

Cellular Component: presynaptic membrane; cell surface; endocytic vesicle; cell; integral to membrane; plasma membrane; cell junction

Molecular Function: protein binding; calcium channel regulator activity; acetylcholine receptor binding; calcium ion binding; cell adhesion molecule binding; calcium-dependent protein binding; receptor binding

Biological Process: prepulse inhibition; neurotransmitter secretion; vocal learning; social behavior; learning; positive regulation of synaptic transmission, glutamatergic; cerebellar granule cell differentiation; negative regulation of filopodium formation; heterophilic cell adhesion; positive regulation of synaptogenesis; synaptic transmission; establishment of protein localization; synaptogenesis; adult behavior; calcium-dependent cell-cell adhesion; protein heterotetramerization; neuron adhesion; angiogenesis; cell adhesion; neuromuscular process controlling balance; vesicle docking during exocytosis