Rabbit anti-Human SLC5A3 Polyclonal Antibody | anti-SLC5A3 antibody
SLC5A3, CT (Solute Carrier Family 5 Member 3, Na(+)/myo-inositol Cotransporter, Sodium/myo-inositol Cotransporter, SMIT, Sodium/myo-inositol Cotransporter 1)
Gene Names
SLC5A3; SMIT; SMIT1; SMIT2
Reactivity
Human
Applications
Immunohistochemistry
Purity
Affinity PurifiedPurified by immunoaffinity chromatography.
Synonyms
SLC5A3; Polyclonal Antibody; CT (Solute Carrier Family 5 Member 3; Na(+)/myo-inositol Cotransporter; Sodium/myo-inositol Cotransporter; SMIT; Sodium/myo-inositol Cotransporter 1); Anti -SLC5A3; anti-SLC5A3 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes an epitope within the C-terminal region of human SLC5A3.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.
Applicable Applications for anti-SLC5A3 antibody
Immunohistochemistry (IHC)
Application Notes
Suitable for use in Immunohistochemistry.
Dilution: Immunohistochemistry (paraffin): 10-30ug/ml
Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
Dilution: Immunohistochemistry (paraffin): 10-30ug/ml
Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher.
Immunogen
Synthetic peptide corresponding to the C-terminal domain of human SLC5A3 (KLH).
Positive Control
Spinal cord
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-SLC5A3 antibody
SLC5A3, also known as SMIT-1, is a membrane associated transporter which is expressed in many human tissues including the brain, kidney and placenta. It is up-regulated in hypertonic conditions and functions in cellular osmoregulation by regulating myo-inositol (MI) uptake. MI is the precursor for phosphatidylinositol and its derivatives, all of which have functions in signal transduction. It is approximately 80kD in size.
Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome.
Up-regulation of SLC5A3 may be associated with an increased risk for bipolar I disorder, and is also thought to be a factor in the pathophysiology of Down syndrome.
Product Categories/Family for anti-SLC5A3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
79,694 Da
NCBI Official Full Name
sodium/myo-inositol cotransporter
NCBI Official Synonym Full Names
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
NCBI Official Symbol
SLC5A3
NCBI Official Synonym Symbols
SMIT; SMIT1; SMIT2
NCBI Protein Information
sodium/myo-inositol cotransporter; BCW2 protein; Na(+)/myo-inositol cotransporter; solute carrier family 5 member 3; sodium/myo-inositol transporter 1; sodium/myo-inositol cotransporter 1; solute carrier family 5 (inositol transporter), member 3; solute carrier family 5 (inositol transporters), member 3; human solute carrier family 5, member 3, Sodium/myo-inositol cotransporter
UniProt Protein Name
Sodium/myo-inositol cotransporter
Protein Family
UniProt Gene Name
SLC5A3
UniProt Synonym Gene Names
Na(+)/myo-inositol cotransporter; SMIT1
UniProt Entry Name
SC5A3_HUMAN
Uniprot Description
SLC5A3: a sodium/myo-inositol cotransporter. An integral membrane protein. Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function. Belongs to the sodium:solute symporter (SSF) family.
Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane
Molecular Function: myo-inositol:sodium symporter activity
Biological Process: regulation of respiratory gaseous exchange; transport; inositol metabolic process; myo-inositol transport; sodium ion transport; transmembrane transport; peripheral nervous system development
Research Articles on SLC5A3
Similar Products
Product Notes
The SLC5A3 slc5a3 (Catalog #AAA621086) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SLC5A3, CT (Solute Carrier Family 5 Member 3, Na(+)/myo-inositol Cotransporter, Sodium/myo-inositol Cotransporter, SMIT, Sodium/myo-inositol Cotransporter 1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SLC5A3 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC). Suitable for use in Immunohistochemistry. Dilution: Immunohistochemistry (paraffin): 10-30ug/ml Requires antigen retrieval using heat treatment prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. Researchers should empirically determine the suitability of the SLC5A3 slc5a3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SLC5A3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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