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Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer using INHBB Polyclonal Antibody at dilution of 1/40)

Rabbit INHBB Polyclonal Antibody | anti-INHBB antibody

INHBB Polyclonal Antibody

Reactivity
Human, Mouse, Rat
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Antigen Affinity Purification
Synonyms
INHBB; Polyclonal Antibody; INHBB Polyclonal Antibody; anti-INHBB antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Affinity Purification
Concentration
2.8mg/ml (varies by lot)
Sequence Length
65
Applicable Applications for anti-INHBB antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
ELISA: 1:2000-5000
IHC: 1:30-150
WB: 1:500-2000
Immunogen
Synthetic peptide of human INHBB
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6307 / sc-6306 / sc-50287
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer using INHBB Polyclonal Antibody at dilution of 1/40)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human liver cancer using INHBB Polyclonal Antibody at dilution of 1/40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer using INHBB Polyclonal Antibody at dilution of 1/40)

Immunohistochemistry (IHC) (Immunohistochemistry of paraffin-embedded Human thyroid cancer using INHBB Polyclonal Antibody at dilution of 1/40)
Related Product Information for anti-INHBB antibody
The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
45 kDa
NCBI Official Full Name
INHBB protein
NCBI Official Synonym Full Names
inhibin beta B subunit
NCBI Official Symbol
INHBB
NCBI Protein Information
inhibin beta B chain
UniProt Protein Name
Inhibin beta B chain
Protein Family
UniProt Gene Name
INHBB
UniProt Entry Name
INHBB_HUMAN

NCBI Description

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

Uniprot Description

INHBB: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2cen-q13

Cellular Component: extracellular region; extracellular space; perinuclear region of cytoplasm

Molecular Function: cytokine activity; hormone activity; host cell surface receptor binding; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; cell development; cellular response to insulin stimulus; cellular response to starvation; defense response; fat cell differentiation; negative regulation of follicle-stimulating hormone secretion; negative regulation of hepatocyte growth factor biosynthetic process; negative regulation of insulin secretion; positive regulation of follicle-stimulating hormone secretion; regulation of apoptosis; regulation of MAPKKK cascade; response to mechanical stimulus

Research Articles on INHBB

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Product Notes

The INHBB inhbb (Catalog #AAA2542748) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INHBB Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's INHBB can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). ELISA: 1:2000-5000 IHC: 1:30-150 WB: 1:500-2000. Researchers should empirically determine the suitability of the INHBB inhbb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INHBB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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