anti-Human APOBEC1 Polyclonal Antibody | anti-APOBEC1 antibody
Anti - APOBEC1 (Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 1)
Gene Names
APOBEC1; BEDP; HEPR; CDAR1; APOBEC-1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified by immunoaffinity chromatography.
Synonyms
APOBEC1; Polyclonal Antibody; Anti - APOBEC1 (Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 1); APOBEC1 (Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 1); anti-APOBEC1 antibody
Host
Host: Rabbit
Source: Human
Source: Human
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human APOBEC1.
Purity/Purification
Purified by immunoaffinity chromatography.
Form/Format
Affinity Purified
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Concentration
~1mg/ml (varies by lot)
Sequence Length
223
Applicable Applications for anti-APOBEC1 antibody
ELISA, Western Blot
Application Notes
Western Blot: 1-10ug/ml using ECL technique.
ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml
ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml
Immunogen
16aa peptide from human Apobec-1 located at ~C-terminus.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-APOBEC1 antibody
RNA editing is an important mechanism for regulating genetic plasticity through the generation of alternative protein productsfrom a single structural gene. Substitutional RNA editing employsa variety of genetic mechanisms, the biochemical basis of whichhas been elucidated following the development of in vitro assaysthat recapitulate important elements of this process. There are two typesof substitutional RNA exist in mammals, namely A-to-I and C-to-URNA editing. The best-characterized example of C-to-U RNA editing involves the nuclear transcript encoding intestinal apolipoprotein B(apo B)). Apo B RNA editing changes a CAA to a UAA stop codon,generating a truncated protein, apoB48. The functional complex includes a minimal corecomposed of apobec-1 and ACF, that functionas an adaptor protein by binding both the deaminase and the RNA substrate. The RNA binding proteins also include CUGBP2 which along with Apobec-1 binds to the consensus binding sequence UUUN (A/U) U, present in c-myc, VEGF and Cyclooxygenase-2 (COX2).
Product Categories/Family for anti-APOBEC1 antibody
References
• Shrikant Anant et al (2001) JBC, Vol. 276, No: 50, 47338-47351; Duanxiang Li et al (2001) Genomics 74, 396-401; Ba-Bie Teng et al (1999) J. of Lipid Research, Vol. 40, 623-633; Lu X et al (1999) Hum. Mol. Genet. 8 (1), 53-60; Fujino, T. et al (1998) Genomics 47 (2), 266-275.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
26,771 Da
NCBI Official Full Name
APOBEC1 protein
NCBI Official Synonym Full Names
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
NCBI Official Symbol
APOBEC1
NCBI Official Synonym Symbols
BEDP; HEPR; CDAR1; APOBEC-1
NCBI Protein Information
C->U-editing enzyme APOBEC-1; OTTHUMP00000180598; apolipoprotein B mRNA-editing enzyme 1; apolipoprotein B mRNA editing enzyme complex-1
UniProt Protein Name
APOBEC1 protein
Protein Family
UniProt Gene Name
APOBEC1
UniProt Entry Name
Q4VB33_HUMAN
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Product Notes
The APOBEC1 apobec1 (Catalog #AAA620321) is an Antibody produced from Host: Rabbit Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti - APOBEC1 (Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's APOBEC1 can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot. Western Blot: 1-10ug/ml using ECL technique. ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml. Researchers should empirically determine the suitability of the APOBEC1 apobec1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "APOBEC1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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