Rabbit anti-Human, Mouse Tankyrase Polyclonal Antibody | anti-tankyrase antibody
Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase)
Gene Names
tankyrase; BcDNA:LD22548; CG17487; CG4719; DmelCG4719
Reactivity
Human, Mouse
Applications
ELISA, Western Blot
Purity
SerumSerum
Synonyms
Tankyrase; Polyclonal Antibody; Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase); Anti -Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase); anti-tankyrase antibody
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase). The human T0900-15 petide sequence is not found in TANK-1 isoform 2. Species Sequence Homology: 100% conserved in mouse TANK1. Minimal sequence conservation with TANK2.
Purity/Purification
Serum
Serum
Serum
Form/Format
Supplied as a lyophilized powder from PBS, 0.05% sodium azide.
Applicable Applications for anti-tankyrase antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-50,000.
Dilution: Western Blot: 1:1000-1:5000
ELISA: 1:10,000-50,000.
Immunogen
A 21aa peptide sequence near the C-terminus of human tankyrase, PARP domain (KLH coupled).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-tankyrase antibody
The 3'ends of chromosomes are capped with telomere sequences (TTAGGG; 6-26 nucleotides in length) by ribonucleoprotein telomerase during DNA replication. 4.8 kb of telomeric DNA is lost with each cell division. Telomere length is maintained by regulating the activity of telomerase. Purification of telomerase from the ciliate also revealed two protein of 43 and 123kD. p123 is a homolog of yeast Est2 and shows 20% homology. Mammalian homologs of yeast Est2 (also known as TP2 for Telomerase associated Protein 2; hEST2 or telomerase catalytic subunit or telomerase reverse transcriptase, TERT) have also been cloned (human Est2, 1132 aa; ~127kD). hEST2 was localized in the nucleus. It is associated with telomerase activity and TP1. Telomeric Repeat binding Factors (TRF1 and TRF2) bind the telomeric TTAGGG repeat. TRFs have been colocalized with telomeric DNA in metaphase cells. TRFs are located at chromosome ends during metaphase. TRF2 protects chromosome ends and TRF1 regulates telomere length. Over expression of TRF1 resulted into telomere shortening, whereas inhibition of TRF1 increased telomere length. Most recently, Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase; human 1327 aa), a protein with homology to ankyrins and poly(adenosine diphosphate-ribose) polymerase (PARP) has been cloned and localized to telomere. Tankyrase binds to TRF1. It contains 24 ankyrin repeats in TRF-1 interacting domain. Tankyrase has PARP activity in vitro, with both TRF1 and tankyrase acting as acceptor for ADP-ribosylation.
Product Categories/Family for anti-tankyrase antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
127,945 Da
NCBI Official Full Name
tankyrase
NCBI Official Symbol
tankyrase
NCBI Official Synonym Symbols
BcDNA:LD22548; CG17487; CG4719; DmelCG4719
NCBI Protein Information
CG4719 gene product from transcript CG4719-RA; tankyrase; CG4719-PA; tankyrase-PA
UniProt Protein Name
FI03751p
Protein Family
UniProt Gene Name
tankyrase
UniProt Synonym Gene Names
tankyrase-RA
UniProt Entry Name
Q9VBP3_DROME
Uniprot Description
Sequence similarities: Contains 1 PARP catalytic domain. SAAS SAAS012317Contains 1 SAM (sterile alpha motif) domain. SAAS SAAS010993
Similar Products
Product Notes
The tankyrase tankyrase (Catalog #AAA618039) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Tankyrase (TRF1 interacting ankyrin-related ADP-ribose polymerase) reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Tankyrase can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:1000-1:5000 ELISA: 1:10,000-50,000. Researchers should empirically determine the suitability of the tankyrase tankyrase for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tankyrase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
