Rabbit IP3 Type II Receptor Polyclonal Antibody | anti-Itpr1 antibody
IP3 Type II Receptor (Type II Inositol 1,4,5-Trisphosphate Receptor)
Purified by Immunoaffinity chromatography.
Purified by Immunoaffinity chromatography.
Dilution: Western Blot: 1:50-1:100 (detects a ~260kD band)
Immunofluorescence: 1:10-1:20
Immunohistochemistry: Paraformaldehyde or methanol fixed sections.
Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293 and RBL-2H3 cell lines.
Optimal dilution determined by the researcher.
NCBI and Uniprot Product Information
NCBI Description
This gene belongs to the Insp3 receptor family. It encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Uniprot Description
IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described.
Protein type: Membrane protein, multi-pass; Channel, calcium; Channel, ligand-gated; Membrane protein, integral
Cellular Component: endoplasmic reticulum membrane; protein complex; intracellular membrane-bound organelle; sarcoplasmic reticulum; cell; secretory granule membrane; endoplasmic reticulum; dendrite; postsynaptic density; integral to membrane; nuclear inner membrane; nuclear envelope; cytosol; calcineurin complex; lipid raft; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; nucleolus; platelet dense granule membrane; intracellular
Molecular Function: protein C-terminus binding; protein binding; protein complex binding; calcium channel inhibitor activity; intracellular ligand-gated calcium channel activity; protein phosphatase binding; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity
Biological Process: negative regulation of calcium-mediated signaling; elevation of cytosolic calcium ion concentration; endoplasmic reticulum calcium ion homeostasis; inositol phosphate-mediated signaling; voluntary musculoskeletal movement; calcium ion transport; release of sequestered calcium ion into cytosol; response to hypoxia; positive regulation of calcium ion transport; post-embryonic development
Research Articles on Itpr1
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Product Notes
The Itpr1 itpr1 (Catalog #AAA617710) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The IP3 Type II Receptor (Type II Inositol 1,4,5-Trisphosphate Receptor) reacts with Hamster, Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's IP3 Type II Receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF). Suitable for use in Western Blot, Immunofluorescence, Immunoprecipitation, Immunocytochemistry and Immunohistochemistry. Dilution: Western Blot: 1:50-1:100 (detects a ~260kD band) Immunofluorescence: 1:10-1:20 Immunohistochemistry: Paraformaldehyde or methanol fixed sections. Immunocytochemistry: Known to give positive reactivity on AR4-2J, HL-60, COS-I, HEK-293 and RBL-2H3 cell lines. Optimal dilution determined by the researcher. Researchers should empirically determine the suitability of the Itpr1 itpr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IP3 Type II Receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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