Chemical Structure
Nutlin-3, Inhibitor
Nutlin-3
Purity
>98%
Synonyms
Nutlin-3; Nutlin3; inhibitor
Purity/Purification
>98%
Form/Format
Powder
Concentration
0.1 mM: 17.2 mL (1 mg); 85.98 mL (5 mg); 171.97mL (10 mg)
0.5 mM: 3.44 mL (1 mg); 17.2 mL (5 mg); 34.39 mL (10 mg)
1 mM: 1.72 mL (1 mg); 8.6 mL (5 mg); 17.2 mL (10 mg)
5 mM: 0.34 mL (1 mg); 1.72 mL (5 mg); 3.44 mL (10 mg) (varies by lot)
0.5 mM: 3.44 mL (1 mg); 17.2 mL (5 mg); 34.39 mL (10 mg)
1 mM: 1.72 mL (1 mg); 8.6 mL (5 mg); 17.2 mL (10 mg)
5 mM: 0.34 mL (1 mg); 1.72 mL (5 mg); 3.44 mL (10 mg) (varies by lot)
CAS Number
548472-68-0
Formula
C30H30Cl2N4O4
SMILES
CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl
Actions
Antagonist
Availability
We cannot ship this item to Switzerland, Italy, Germany, France and Austria.
Preparation and Storage
at -20 degree C 3 years Powder
Chemical Structure
Chemical Structure
Related Product Information for Nutlin-3, inhibitor
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis.
References
Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749-1763 PMID: 29743291
Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64-71 PMID: 26771712
A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376
Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64-71 PMID: 26771712
A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376
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Product Notes
The Nutlin-3 (Catalog #AAA385838) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nutlin-3, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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