Rabbit anti-Mouse CABP9K Polyclonal Antibody | anti-S100g antibody

CABP9K (D9K, CALB3, CABP1)

Cat. Num. AAA617498

• Gene Names: S100g; CABP1; Calb3; Cabp9k; AU042539; CaBP-D9K
• Reactivity: Mouse
• Applications: ELISA, Western Blot
• Purity: Serum; Serum
• Synonyms: CABP9K; Polyclonal Antibody; CABP9K (D9K; CALB3; CABP1); Anti -CABP9K (D9K; anti-S100g antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes mouse CABP9K at ~9kD. No significant sequence homology is seen with D28K or other CABPs.
• Purity/Purification: Serum; Serum
• Form/Format: Supplied as a liquid in PBS, 0.05% sodium azide.

• Applicable Applications for anti-S100g antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:10,000-1:100,000 using 50-100ng C0104-60 Control peptide/well.; Western Blot: 1:1000-1:5000 using ECL.
• Immunogen: Synthetic peptide corresponding to 16aa within the N-terminal Ca-binding domain of mouse CABP9K. Species Sequence Homology: Rat (82%), porcine (75%), bovine (62%), human (56%).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-S100g antibody

Calcium is the most abundant cation and is required for many physiological activities and acts as a second messenger in signal transduction. Only 1% of Ca is present in ionic form in biological fluids. Ca concentration is regulated by calcitropic hormones that act on bone, kidney and intestine. Extracellular Ca+- levels are sensed and regulated by Calcium Sensing receptor (CASR). When Ca levels are limiting then it must be taken up by active, transcellular pathways. Calbindins are Ca-binding proteins belonging to the troponin C superfamily. There are two types of CaBPs: the "trigger" and the "buffer" CaBPs. The conformation of "trigger" type CaBPs changes upon Ca2+ binding and exposes regions on proteins that interact with target molecules, thus altering their activity. The buffer-type CABP are thought to control the intracellular calcium concentration. CABP9K (mouse, rat and human 79aa; chromosome Xp; ~9kD) is a cytosolic Ca-binding protein initially found in rat pancreas. It is also expressed in intestine, placenta, uterus and kidney. Its expression is controlled by vitamin D and sex hormone in a tissue specific manner. In keeping with its role in Ca- transport, its expression is highest in duodenal villus enterocytes. It is further shown that CABP9K is only expressed in differentiated enterocytes. CABP9K gene also contains Cdx2-homeoprotein binding sites, and that Cdx2 may play a crucial role in CABP9K transcription.

Product Categories/Family for anti-S100g antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 2599052
• NCBI GeneID: 12309
• UniProt Accession #: P97816; Q5VM59; Q91XG5
• Molecular Weight: 8,970 Da
• NCBI Official Full Name: calcium binding protein D-9k
• NCBI Official Synonym Full Names: S100 calcium binding protein G
• NCBI Official Symbol: S100g
• NCBI Official Synonym Symbols: CABP1; Calb3; Cabp9k; AU042539; CaBP-D9K
• NCBI Protein Information: protein S100-G; CABP; calbindin D9k; OTTMUSP00000021020; calbindin-D9K major form; S100 calcium-binding protein G; cytidine 5'-triphosphate synthase 2; vitamin D-dependent calcium-binding protein, intestinal; calbindin 3, (vitamin D-dependent calcium binding protein)
• UniProt Protein Name: Protein S100-G
• Protein Family: Protein
• UniProt Gene Name: S100g
• UniProt Synonym Gene Names: Calb3; S100d
• UniProt Entry Name: S100G_MOUSE

Uniprot Description

S100G: calbindin D9K, a vitamin D-dependent calcium-binding protein. This cytosolic protein belongs to a family of calcium-binding proteins that includes calmodulin, parvalbumin, troponin C, and S100 protein. In the intestine, the protein is vitamin D-dependent and its expression correlates with calcium transport activity. The protein may increase Ca2+ absorption by buffering Ca2+ in the cytoplasm and increase ATP-dependent Ca2+ transport in duodenal basolateral membrane vesicles. [provided by RefSeq, Jul 2008]

Cellular Component: basolateral plasma membrane; apical plasma membrane

Molecular Function: vitamin D binding; metal ion binding; calcium ion binding