Rabbit anti-Rat Taste Receptor 1 Polyclonal Antibody | anti-TAS1R1 antibody

Taste Receptor 1 (TR1)

Cat. Num. AAA617369

• Gene Names: TAS1R1; TR1; T1R1; GM148; GPR70
• Reactivity: Rat
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Taste Receptor 1; Polyclonal Antibody; Taste Receptor 1 (TR1); Anti -Taste Receptor 1 (TR1); anti-TAS1R1 antibody

• Host: Rabbit
• Reactivity: Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes rat TR1. It has no significant sequence homology with TR2 or gustducin or pheromone receptors.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as liquid in 100mM Tris, pH 7.5 and 0.2% BSA, 0.05% sodium azide, 40% glycerol.

• Applicable Applications for anti-TAS1R1 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1-10ug/ml using ECL.; ELISA: 0.5-1ug/ml Control peptide can be used to coat ELISA plates at 1ug/ml.
• Immunogen: A 24 AA Peptide sequence near the C-terminus of rat TR1(1) (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-TAS1R1 antibody

Higher vertebrates are believed to possess at least five basic tastes: Sweet, bitter, sour, salty, and unami (the taste of monosodium glutamate). Taste receptor cells that may selectively reside in various parts of the tongue and respond to different tastants and perceive these taste modalities. Circumvallate papillae, found at the very back of the tongue, are particularly sensitive to biter substances. Foliate papillae, found at the posterior lateral edge of the tongue, are sensitive to sour and bitter. Fungiform papillae at the front of the tongue specialize in sweet taste. Recently, two novel taste receptors, TR1 and TR2, have been cloned with distinct topographical distribution in taste receptor cells and taste buds. TRs are members of a new group of 7 TM domain containing GPCR distantly related to other chemosensory receptors (Ca+-sensing receptor (CaSR, a family of putative hormone receptor (V2R), and metabotropic glutamate receptors). TR1 is expressed in all fungiform taste buds, whereas TR2 localized to the circumvallate taste buds. Both receptors do not co-localize with gustducin.

Product Categories/Family for anti-TAS1R1 antibody

Antibodies; Abs to Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 29294615
• NCBI GeneID: 80835
• NCBI Accession #: NP_619642.2
• NCBI GenBank Nucleotide #: NM_138697.3
• UniProt Accession #: Q7RTX1; Q5SY22; Q5SY24; Q8NGZ7; Q8TDJ7; Q8TDJ8; Q8TDJ9; Q8TDK0; B2RMX0
• Molecular Weight: 93,074 Da
• NCBI Official Full Name: taste receptor type 1 member 1 isoform b
• NCBI Official Synonym Full Names: taste receptor, type 1, member 1
• NCBI Official Symbol: TAS1R1
• NCBI Official Synonym Symbols: TR1; T1R1; GM148; GPR70
• NCBI Protein Information: taste receptor type 1 member 1; G protein-coupled receptor 70; G-protein coupled receptor 70; seven transmembrane helix receptor
• UniProt Protein Name: Taste receptor type 1 member 1
• Protein Family: Taste receptor
• UniProt Gene Name: TAS1R1
• UniProt Synonym Gene Names: GPR70; T1R1; TR1
• UniProt Entry Name: TS1R1_HUMAN

NCBI Description

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

TAS1R1: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 3; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein heterodimerization activity; taste receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; sensory perception of umami taste; detection of chemical stimulus involved in sensory perception of taste