Rabbit T1R1 / TAS1R1 Polyclonal Antibody | anti-T1R1 antibody

Rabbit Polyclonal to Human T1R1 / TAS1R1

Cat. Num. AAA244958

• Gene Names: TAS1R1; TR1; T1R1; GM148; GPR70
• Reactivity: Human; Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: Immunoaffinity Purified
• Synonyms: T1R1 / TAS1R1; Polyclonal Antibody; Rabbit Polyclonal to Human T1R1 / TAS1R1; Anti-T1R1 / TAS1R1 Antibody (N-Terminus) IHC-plus; TAS1R1; G-protein coupled receptor 70; GPR70; GM148; GPCRB3; G protein-coupled receptor 70; GPCR-B3; T1R1; Taste receptor type 1 member 1; TR1; Human T1R1; anti-T1R1 antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human TAS1R1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 841

• Applicable Applications for anti-T1R1 antibody: Immunohistochemistry (IHC - Paraffin), Flow Cytometry (FC/FACS)
• Application Notes: Flo, IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human TAS1R1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey (94%); Marmoset (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: T1R1 / TAS1R1 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human TAS1R1. Percent identity with other species by BLAST analysis: Human (100%); Gorilla, Gibbon, Monkey (94%); Marmoset (83%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-T1R1 / TAS1R1 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-TAS1R1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-T1R1 antibody

TAS1R1 is a Taste Receptor. TAS1R1 combines with TAS1R3 to function as an L-amino-acid receptor and is only activated by these sweet amino acids.

Product Categories/Family for anti-T1R1 antibody

Family: GPCR; Subfamily: Taste

NCBI and Uniprot Product Information

• NCBI GI #: 29294615
• NCBI GeneID: 80835
• NCBI Accession #: NP_619642.2
• NCBI GenBank Nucleotide #: NM_138697.3
• UniProt Accession #: Q7RTX1; Q5SY22; Q5SY24; Q8NGZ7; Q8TDJ7; Q8TDJ8; Q8TDJ9; Q8TDK0; B2RMX0
• Molecular Weight: 35,134 Da
• NCBI Official Full Name: taste receptor type 1 member 1 isoform b
• NCBI Official Synonym Full Names: taste receptor, type 1, member 1
• NCBI Official Symbol: TAS1R1
• NCBI Official Synonym Symbols: TR1; T1R1; GM148; GPR70
• NCBI Protein Information: taste receptor type 1 member 1; G protein-coupled receptor 70; G-protein coupled receptor 70; seven transmembrane helix receptor
• UniProt Protein Name: Taste receptor type 1 member 1
• UniProt Gene Name: TAS1R1
• UniProt Synonym Gene Names: GPR70; T1R1; TR1
• UniProt Entry Name: TS1R1_HUMAN

NCBI Description

The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Description

TAS1R1: Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. Belongs to the G-protein coupled receptor 3 family. TAS1R subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 3; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.23

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein heterodimerization activity; taste receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; sensory perception of umami taste; detection of chemical stimulus involved in sensory perception of taste