Rabbit anti-Human Anion Exchanger 4 Polyclonal Antibody | anti-SLC4A9 antibody

Anion Exchanger 4 (AE4)

Cat. Num. AAA613692

• Gene Names: SLC4A9; AE4
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Anion Exchanger 4; Polyclonal Antibody; Anion Exchanger 4 (AE4); Anti -Anion Exchanger 4 (AE4); anti-SLC4A9 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human AE4. Sequence homology
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA.

• Applicable Applications for anti-SLC4A9 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: Western Blot: 1-10ug/ml (ECL); ELISA: 0.5-1ug/ml. Coat ELISA plates at 1ug/ml with A2295-14G2 Anion Exchanger 4, Control Peptide Human.
• Immunogen: Synthetic peptiide corresponding to 15aa near the cytoplasmic C-terminus of human AE4 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-SLC4A9 antibody

Anion exchangers (AE) are membranes proteins involved in the regulation of intracellular pH, cell volume regulation as well as in transepithelial acid/base transport. AE proteins are sodium-independent exchangers that mediates one-for-one exchange of extracellular Cl- for intracellular HCO3- ions resulting in intracellular acidification. AE proteins are encoded by a family of at least three related genes (AE1, AE2, and AE3). Numerous alternatively spliced isoforms of each AE gene are expressed in various tissues. AE proteins are exemplified by a large N-terminal cytoplasmic domain (~40-75kD) that provides binding sites for cytoskeleton protein, glycolytic enzymes and hemoglobin. The N-terminal cytoplasmic domains of AE2 are AE3 are more closely related than AE1. In fact, AE1 N-terminus is 300aa shorter than both the AE2 and AE3. The C-terminal TM domain (~55kD) is highly conserved (~70% identity) among various AE, spans the lipid bilayer 12-14 times, and is able to mediate anion exchange by itself.

Product Categories/Family for anti-SLC4A9 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 151101449
• NCBI GeneID: 83697
• NCBI Accession #: NP_113655.2
• NCBI GenBank Nucleotide #: NM_031467.2
• UniProt Accession #: Q96Q91; Q96RM5; Q9BXF2; Q9BXN3; D3DQD4; D3DQD5; D3DQD6
• Molecular Weight: 108,248 Da
• NCBI Official Full Name: anion exchange protein 4
• NCBI Official Synonym Full Names: solute carrier family 4, sodium bicarbonate cotransporter, member 9
• NCBI Official Symbol: SLC4A9
• NCBI Official Synonym Symbols: AE4
• NCBI Protein Information: anion exchange protein 4; AE 4; anion exchanger 4; OTTHUMP00000223645; OTTHUMP00000223646; OTTHUMP00000223647; OTTHUMP00000223648; solute carrier family 4 member 9; sodium bicarbonate cotransporter 5; solute carrier family 4, sodium bicarbonate cotransporter-like, member 9
• UniProt Protein Name: Anion exchange protein 4
• Protein Family: Anion exchange protein
• UniProt Gene Name: SLC4A9
• UniProt Synonym Gene Names: AE4; SBC5
• UniProt Entry Name: B3A4_HUMAN

NCBI Description

The protein encoded by this gene is a membrane protein involved in anion exchange. Expression of this gene is mostly limited to the kidney. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Uniprot Description

SLC4A9: Probable apical anion exchanger of the kidney cortex. Belongs to the anion exchanger (TC 2.A.31) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Transporter, SLC family; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: apical part of cell; integral to plasma membrane; plasma membrane

Molecular Function: inorganic anion exchanger activity; sodium:bicarbonate symporter activity

Biological Process: bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport