Western Blot (WB)
(Western Blot analysis of MBS612762: Lane 1: MW Marker, Lane 2: HeLa, (Cell Lysate), Lane 3: Brain (mouse), (tissue extract), Lane 4: Brain (rat), (tissue extract))
Rabbit SAPK2, p38 Polyclonal Antibody
SAPK2, p38 (Stress-activated Protein Kinase 2, HOG1)
Reactivity
Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
Applications
Western Blot, Immunoprecipitation
Purity
Serum
Synonyms
SAPK2; p38; Polyclonal Antibody; p38 (Stress-activated Protein Kinase 2; HOG1); Anti -SAPK2; anti-SAPK2; p38 antibody
Host
Rabbit
Reactivity
Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
Clonality
Polyclonal
Isotype
IgG
Specificity
This antibody detects an ~43kD protein, corresponding to the apparent molecular mass of p38 (HOG1) on SDS-PAGE immunoblots, in samples from human, monkey, mouse, rat, bovine, rabbit, porcine, canine, hamster, chicken, sheep and guinea pig.
Purity/Purification
Serum
Form/Format
Serum
Applicable Applications for anti-SAPK2, p38 antibody
Western Blot (WB), Immunoprecipitation (IP)
Immunogen
A 20 residue synthetic peptide (C)TYDEVISFVPPPLDQEEMES based on the human p38 (residues 341-360) with the cysteine (C) residue added and the peptide coupled to KLH. This sequence is identical to mouse p38 over these residues.
Preparation and Storage
-20 degree C
Western Blot (WB)
(Western Blot analysis of MBS612762: Lane 1: MW Marker, Lane 2: HeLa, (Cell Lysate), Lane 3: Brain (mouse), (tissue extract), Lane 4: Brain (rat), (tissue extract))
Western Blot (WB)
(Western Blot analysis of MBS612762: Lane 1: MW Marker, Lane 2: HeLa, (Cell Lysate), Lane 3: Brain (mouse), (tissue extract), Lane 4: Brain (rat), (tissue extract))
Immunohistochemistry (IHC)
(IHC Analysis: Human tonsil tissue stained with MBS612762 at 10ug/ml.)
Immunohistochemistry (IHC)
(IHC Analysis: Human tonsil tissue stained with MBS612762 at 10ug/ml.)
Related Product Information for anti-SAPK2, p38 antibody
p38 (HOG1), also known as SAPK-2, reactivating kinase or cytokine-suppressive binding protein, is a mouse 38 kD serine threonine kinase that belongs to the mitogen-activated protein kinase family (1). p38 is identified as one of the major tyrosine-phosphorylated proteins in mouse monocyte cell lines upon lipopolysachharide (LPS) treatment (2). Human homolog of p38 binds to cytokines suppressive anti-inflammatory drugs (CSAIDs), an anti-inflammatory drug that inhibits IL-1 and TNF-a synthesis (1). HOG1, the yeast homolog of p38, is stimulated by osmotic shock (3). p38 is activated by MAPK kinase MKK3 and Sek1/MKK4, the latter kinase is also involved in the activation of the stress-activated protein kinase pathway (4). In LPS-treated monocytic cells, the activity of a transcription activators called myocyte-enhancer factor 2 (MEF2) is increased through p38-catalysed phosphorylation, which results in increased c-jun gene transcription (5). p38 also activates MAPKAP kinase 2 in IL-1-stimulated cells (6).
Product Categories/Family for anti-SAPK2, p38 antibody
Similar Products
Product Notes
The SAPK2, p38 (Catalog #AAA612762) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The SAPK2, p38 (Stress-activated Protein Kinase 2, HOG1) reacts with Bovine, Canine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's SAPK2, p38 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the SAPK2, p38 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SAPK2, p38, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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