Rabbit anti-Mouse, Rat MuSK Polyclonal Antibody | anti-MUSK antibody

MuSK (Muscle/Skeletal Receptor Tyrosine Protein Kinase, Muscle Skeletal Receptor Tyrosine Kinase, MDK4, MGC126323, MGC126324, Muscle Specific Kinase Receptor, Muscle Specific Tyrosine Kinase Receptor, Muscle Specific Tyrosine Protein Kinase Receptor, Neur

Cat. Num. AAA611795

• Reactivity: Mouse, Rat
• Applications: Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: MuSK; Polyclonal Antibody; MuSK (Muscle/Skeletal Receptor Tyrosine Protein Kinase; Muscle Skeletal Receptor Tyrosine Kinase; MDK4; MGC126323; MGC126324; Muscle Specific Kinase Receptor; Muscle Specific Tyrosine Kinase Receptor; Muscle Specific Tyrosine Protein Kinase Receptor; Neur; Anti -MuSK (Muscle/Skeletal Receptor Tyrosine Protein Kinase; anti-MUSK antibody

• Host: Rabbit
• Reactivity: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Detects MUSK from mouse and rat tissue samples as well as COS7 cells transfected with rat MUSK. Species Crossreactivity: Crossreacts with Mouse and Rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: 10% Glycerol, PBS, 1mg/ml BSA

• Applicable Applications for anti-MUSK antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blot and Immunoprecipitation.
• Immunogen: Fusion protein, corresponding to amino acids 210-304 from the extracellular domain of Rat MUSK.
• Positive Control: Mouse C2C12 cell lysate. MUSK transfected COS7 cell lysate.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot Store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-MUSK antibody

Communication between cells is often mediated by receptors on the surface of the target cell that are triggered by specific ligands released by other cells. Receptor tyrosine kinase activity is strictly regulated by the binding of the appropriate ligand to the extracellular active site of the receptor. These types of receptors play a role critical in the growth and differentiation of different cell types. A muscle specific kinase recently identified, termed MUSK for muscle-specific kinase, and has been shown to be specifically expressed in the muscle cells within the neuromuscular junction. MUSK has been shown to be part of the agrin signaling complex and plays an important role in the development and architectural maintenance of the neuromuscular junction.

Product Categories/Family for anti-MUSK antibody

Antibodies; Abs to Protein Kinases

NCBI and Uniprot Product Information

• NCBI GI #: 261878457
• NCBI GeneID: 4593
• NCBI Accession #: NP_001159753.1
• NCBI GenBank Nucleotide #: NM_001166281.1
• UniProt Accession #: O15146; Q32MJ8; Q32MJ9; Q5VZW7; Q5VZW8
• Molecular Weight: 97,056 Da
• NCBI Official Full Name: muscle, skeletal receptor tyrosine-protein kinase isoform 3
• NCBI Official Synonym Full Names: muscle, skeletal, receptor tyrosine kinase
• NCBI Official Symbol: MUSK
• NCBI Protein Information: muscle, skeletal receptor tyrosine-protein kinase; muscle-specific kinase receptor; muscle-specific tyrosine-protein kinase receptor
• UniProt Protein Name: Muscle, skeletal receptor tyrosine-protein kinase
• Protein Family: Muskelin
• UniProt Gene Name: MUSK
• UniProt Synonym Gene Names: MuSK
• UniProt Entry Name: MUSK_HUMAN

NCBI Description

This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]

Uniprot Description

MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.

Protein type: Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; EC 2.7.10.1; Membrane protein, integral; TK group; Musk family

Chromosomal Location of Human Ortholog: 9q31.3-q32

Cellular Component: postsynaptic membrane; integral to plasma membrane; neuromuscular junction; cell junction; receptor complex

Molecular Function: protein binding; protein-tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: extracellular matrix organization and biogenesis; peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; multicellular organismal development; protein amino acid autophosphorylation; positive regulation of neuron apoptosis; regulation of synaptic growth at neuromuscular junction; positive regulation of protein amino acid phosphorylation; cell differentiation; transmembrane receptor protein tyrosine kinase signaling pathway; neuromuscular junction development; memory

Disease: Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency; Fetal Akinesia Deformation Sequence