Mouse anti-Human MUSK Monoclonal Antibody | anti-MUSK antibody

Anti-MUSK Mouse mAb

Cat. Num. AAA475919

• Gene Names: MUSK; CMS9; FADS
• Reactivity: Human
• Applications: Immunohistochemistry, Immunocytochemistry
• Synonyms: MUSK; Monoclonal Antibody; Anti-MUSK Mouse mAb; muscle; skeletal; receptor tyrosine kinase; anti-MUSK antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10A4
• Form/Format: Ascitic fluid containing 0.03% sodium azide.
• Sequence Length: 773

• Applicable Applications for anti-MUSK antibody: Immunohistochemistry (IHC), Immunocytochemistry (ICC)
• Immunogen: Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.

Immunofluorescence (IF)

(Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular MUSK (aa24-209)-hIgGFc using MUSK mouse mAb (green). Blue)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded human lung cancer (A), muscles (B) and breast cancer (C) using MUSK mouse mAb with DAB staining.)

Related Product Information for anti-MUSK antibody

Entrez Summary: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

NCBI and Uniprot Product Information

• NCBI GI #: 80478934
• NCBI GeneID: 4593
• Molecular Weight: 97
• NCBI Official Full Name: MUSK protein
• NCBI Official Synonym Full Names: muscle associated receptor tyrosine kinase
• NCBI Official Symbol: MUSK
• NCBI Official Synonym Symbols: CMS9; FADS
• NCBI Protein Information: muscle, skeletal receptor tyrosine-protein kinase
• UniProt Protein Name: Muscle, skeletal receptor tyrosine-protein kinase
• Protein Family: Muskelin
• UniProt Gene Name: MUSK
• UniProt Synonym Gene Names: MuSK; Muscle-specific kinase receptor

NCBI Description

This gene encodes a muscle-specific tyrosine kinase receptor. The encoded protein may play a role in clustering of the acetylcholine receptor in the postsynaptic neuromuscular junction. Mutations in this gene have been associated with congenital myasthenic syndrome. Alternatively spliced transcript variants have been described.[provided by RefSeq, Oct 2009]

Uniprot Description

MUSK: a receptor tyrosine kinase that is essential for the establishment and maintenance of the neuromuscular junction (NMJ). Its activation by agrin, a neuronally derived heparan-sulfate proteoglycan, and the agrin receptor (LRP4), leads to clustering of acetylcholine receptors on the postsynaptic side of the NMJ. Its activation by agrin requires Dok7, which interacts with the cytoplasmic portion of MuSK and activates its tyrosine kinase activity.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Musk family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group

Chromosomal Location of Human Ortholog: 9q31.3

Cellular Component: integral to plasma membrane; neuromuscular junction; postsynaptic membrane; receptor complex

Molecular Function: protein binding; protein-tyrosine kinase activity

Biological Process: memory; neuromuscular junction development; positive regulation of protein amino acid phosphorylation; protein amino acid autophosphorylation; regulation of synaptic growth at neuromuscular junction; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Fetal Akinesia Deformation Sequence; Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency