Rabbit anti-Human RAMP2 Polyclonal Antibody | anti-RAMP2 antibody

RAMP2 (Receptor Activity Modifying Protein2)

Cat. Num. AAA611530

• Gene Names: RAMP2; RAMP2
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: RAMP2; Polyclonal Antibody; RAMP2 (Receptor Activity Modifying Protein2); Anti -RAMP2 (Receptor Activity Modifying Protein2); anti-RAMP2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human RAMP2. Species sequence homology: mouse-50%, rat-89%. No significant sequence homology is detected with other RAMPs.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.1% BSA, 40% glycerol.

• Applicable Applications for anti-RAMP2 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 0.5-1ug/ml.; Western Blot: 1-10ug/ml
• Immunogen: Synthetic peptides (20aa and 9aa) from the middle of human RAMP2 (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-RAMP2 antibody

The calcitonin family peptides probably act through G-protein coupled membrane receptors. The gene for calcitonin receptors has been cloned. It is homologous to GPCRs in family "B" which typically recognizes regulatory peptides (secretin, glucagons, VIP). Recently, a homolog of calcitonin receptor, CRLR (calcitonin-receptor-like receptor human 461 aa; rat/mouse 463 aa) was identified. CRLR has 55% homology with calcitonin receptor. It is now shown that CRLR can function as either a CGRP receptor or an ADM receptor, depending upon which members of a new family of proteins called receptor activity modifying proteins (RAMP1-3) are expressed. RAMPs1-3 contains an N-terminal signal peptide, an extracellular N-terminus, a single transmembrane domain near the C-terminus, and cytoplasmic C-terminus. RAMP1-3 displays 31% identity.

Product Categories/Family for anti-RAMP2 antibody

Antibodies; Abs to Transport Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 118572585
• NCBI GeneID: 10266
• NCBI Accession #: NP_005845.2
• NCBI GenBank Nucleotide #: NM_005854.2
• UniProt Accession #: O60895; Q8N1F2
• Molecular Weight: 19,608 Da
• NCBI Official Full Name: receptor activity-modifying protein 2
• NCBI Official Synonym Full Names: receptor (G protein-coupled) activity modifying protein 2
• NCBI Official Symbol: RAMP2
• NCBI Official Synonym Symbols: RAMP2
• NCBI Protein Information: receptor activity-modifying protein 2; CRLR activity-modifying protein 2; receptor activity modifying protein 2; receptor-activity-modifying protein 2; receptor (calcitonin) activity modifying protein 2; calcitonin receptor-like receptor activity modifying protein 2; calcitonin-receptor-like receptor activity-modifying protein 2
• UniProt Protein Name: Receptor activity-modifying protein 2
• Protein Family: Receptor activity-modifying protein
• UniProt Gene Name: RAMP2
• UniProt Entry Name: RAMP2_HUMAN

NCBI Description

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq]

Uniprot Description

RAMP2: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. Belongs to the RAMP family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q12-q21.1

Cellular Component: cell surface; lysosome; integral to plasma membrane; cytoplasm; plasma membrane; coated pit; receptor complex

Molecular Function: protein binding; coreceptor activity; protein transporter activity

Biological Process: heart development; female pregnancy; response to estradiol stimulus; cellular response to hormone stimulus; G-protein coupled receptor protein signaling pathway; intracellular protein transport; protein transport; positive regulation of angiogenesis; receptor internalization; calcium ion transport; regulation of blood pressure; positive regulation of cAMP biosynthetic process; response to hypoxia; negative regulation of vascular permeability; cAMP biosynthetic process; angiogenesis; sprouting angiogenesis; response to progesterone stimulus; vasculogenesis; regulation of G-protein coupled receptor protein signaling pathway