anti-Human Calcitonin Gene Related Peptide-Receptor Component Protein Polyclonal Antibody | anti-CRCP antibody
Anti - Calcitonin Gene Related Peptide-Receptor Component Protein (CGRP-RCP, RCP)
Gene Names
CRCP; RCP; RCP9; CGRPRCP; CGRP-RCP; MGC111194
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Purified by immunoaffinity chromatography.
Synonyms
Calcitonin Gene Related Peptide-Receptor Component Protein; Polyclonal Antibody; Anti - Calcitonin Gene Related Peptide-Receptor Component Protein (CGRP-RCP; RCP); Calcitonin Gene Related Peptide-Receptor Component Protein (CGRP-RCP; anti-CRCP antibody
Host
Host: Rabbit
Source: Human
Source: Human
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Recognizes human CGRP-RCP.
Purity/Purification
Purified by immunoaffinity chromatography.
Form/Format
Affinity Purified
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide, before the addition of glycerol to 40%.
Concentration
~1mg/ml (varies by lot)
Sequence Length
148
Applicable Applications for anti-CRCP antibody
ELISA, Western Blot
Application Notes
Western Blot: 1-10ug/ml using ECL technique.
ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml
ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml
Immunogen
18aa peptide of human CGRP-RCP. Location
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-CRCP antibody
The calcitonin family peptides probably act through G-protein coupled membrane receptors. The gene for calcitonin receptors has been cloned. It is homologous to GPCRs in family "B" which typically recognizes regulatory peptides (secretin, glucagons, VIP). Recently, a homolog of calcitonin receptor, CRLR (calcitonin-receptor-like receptor human 461 aa; rat/mouse 463 aa) was identified. CRLR has 55% homology with calcitonin receptor. It is now shown that CRLR can function as either a CGRP receptor or an ADM receptor, depending upon which members of a new family of proteins called receptor activity modifying proteins (RAMP1-3) are expressed. RAMP1-3 displays 31% identity. RAMPS may be involved in the transport of CRLR to the plasma membrane. RAMP1 (human, mouse, rat 148 aa) presents the CRLR receptor as a glycoprotein that function as CGRP receptor. RAMP1 is expressed in many tissues, including the uterus, bladder, brain, pancreas, and GI tract. CRLR and RAMP1 are not co-expressed in all tissues suggesting that their co-expression may define which cells express functional CGRP receptors.
Product Categories/Family for anti-CRCP antibody
References
• (1). Balkan W et al (1999) Endocrinol. 140, 1459-1469; Luebke AE et al (1996) PNAS 93, 3455-3460; Evans BN et al (2000) J. Biol. Chem. 275, 31438-31443.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
16,871 Da
NCBI Official Full Name
calcitonin gene-related peptide receptor component protein
NCBI Official Synonym Full Names
CGRP receptor component
NCBI Official Symbol
CRCP
NCBI Official Synonym Symbols
RCP; RCP9; CGRPRCP; CGRP-RCP; MGC111194
NCBI Protein Information
DNA-directed RNA polymerase III subunit RPC9; OTTHUMP00000159905; OTTHUMP00000210319; OTTHUMP00000210320; OTTHUMP00000210321; RNA polymerase III subunit C9; CGRP-receptor component protein; calcitonin gene-related peptide-receptor component protein
UniProt Protein Name
DNA-directed RNA polymerase III subunit RPC9
UniProt Gene Name
CRCP
UniProt Entry Name
RPC9_HUMAN
Similar Products
Product Notes
The CRCP crcp (Catalog #AAA611259) is an Antibody produced from Host: Rabbit Source: Human and is intended for research purposes only. The product is available for immediate purchase. The Anti - Calcitonin Gene Related Peptide-Receptor Component Protein (CGRP-RCP, RCP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Calcitonin Gene Related Peptide-Receptor Component Protein can be used in a range of immunoassay formats including, but not limited to, ELISA, Western Blot. Western Blot: 1-10ug/ml using ECL technique. ELISA: 0.5-1ug/ml; Control peptide can be used to coat ELISA plates at 1ug/ml. Researchers should empirically determine the suitability of the CRCP crcp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcitonin Gene Related Peptide-Receptor Component Protein, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
