Rabbit ITGB1BP1 Polyclonal Antibody | anti-ITGB1BP1 antibody

ITGB1BP1 Rabbit Polyclonal

Cat. Num. AAA7600644

• Gene Names: ITGB1BP1; ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: ITGB1BP1; Polyclonal Antibody; ITGB1BP1 Rabbit Polyclonal; anti-ITGB1BP1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 200

• Applicable Applications for anti-ITGB1BP1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Integrin beta 1 binding protein 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human heart tissue slide using MBS7600644 (ITGB1BP1 Antibody) at dilution of 1:200)

Western Blot (WB)

(PC-3 cells were subjected to SDS PAGE followed by western blot with MBS7600644 (ITGB1BP1 antibody) at dilution of 1:300)

NCBI and Uniprot Product Information

• NCBI GI #: 975830191
• NCBI GeneID: 9270
• NCBI Accession #: NP_001305997.1
• NCBI GenBank Nucleotide #: NM_001319068.1
• Molecular Weight: 16,140 Da
• NCBI Official Full Name: integrin beta-1-binding protein 1 isoform 1
• NCBI Official Synonym Full Names: integrin subunit beta 1 binding protein 1
• NCBI Official Symbol: ITGB1BP1
• NCBI Official Synonym Symbols: ICAP1; ICAP1A; ICAP1B; ICAP-1A; ICAP-1B; ICAP-1alpha
• NCBI Protein Information: integrin beta-1-binding protein 1
• UniProt Protein Name: Integrin beta-1-binding protein 1
• Protein Family: Integrin beta-1-binding protein
• UniProt Gene Name: ITGB1BP1
• UniProt Synonym Gene Names: ICAP1; ICAP-1
• UniProt Entry Name: ITBP1_HUMAN

NCBI Description

The cytoplasmic domains of integrins are essential for cell adhesion. The protein encoded by this gene binds to the beta1 integrin cytoplasmic domain. The interaction between this protein and beta1 integrin is highly specific. Two isoforms of this protein are derived from alternatively spliced transcripts. The shorter form of this protein does not interact with the beta1 integrin cytoplasmic domain. The longer form is a phosphoprotein and the extent of its phosphorylation is regulated by the cell-matrix interaction, suggesting an important role of this protein during integrin-dependent cell adhesion. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]

Uniprot Description

ICAP1: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 2p25.2

Cellular Component: cytoplasm; cytoskeleton; cytosol; focal adhesion; lamellipodium; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; ruffle

Molecular Function: GDP-dissociation inhibitor activity; integrin binding; protein binding; protein complex binding; protein kinase binding; protein transporter activity

Biological Process: activation of protein kinase B; biomineral formation; blood vessel endothelial cell proliferation during sprouting angiogenesis; cell differentiation; cell migration; cell-matrix adhesion; integrin activation; integrin-mediated signaling pathway; lumen formation; myoblast migration; negative regulation of cell proliferation; negative regulation of focal adhesion formation; negative regulation of protein binding; negative regulation of protein kinase activity; Notch signaling pathway; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of focal adhesion formation; positive regulation of Notch signaling pathway; positive regulation of protein kinase B signaling cascade; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; protein transport; receptor clustering; regulation of blood vessel size; regulation of cell adhesion mediated by integrin; regulation of GTPase activity; substrate-bound cell migration, cell release from substrate; transcription, DNA-dependent