Mouse anti-Human TRPM2 Monoclonal Antibody | anti-TRPM2 antibody

TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2, Estrogen Responsive Element Associated Gene 1, Estrogen-responsive Element-associated Gene 1 Protein, EREG1, KNP3, Long Transient Receptor Potential Channel 2, LTRPC 2, LTRPC2, LTRPC

Cat. Num. AAA608280

• Gene Names: TRPM2; KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; NUDT9L1; MGC133383
• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation, Immunofluorescence, Immunocytochemistry, Immunohistochemistry
• Purity: Purified by Protein G affinity chromatography.
• Synonyms: TRPM2; Monoclonal Antibody; TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2; Estrogen Responsive Element Associated Gene 1; Estrogen-responsive Element-associated Gene 1 Protein; EREG1; KNP3; Long Transient Receptor Potential Channel 2; LTRPC 2; LTRPC2; LTRPC; Anti -TRPM2 (Transient Receptor Potential Cation Channel Subfamily M Member 2; anti-TRPM2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 10F775
• Specificity: Recognizes human TrpC7. Species Crossreactivity: Mouse and Rat.
• Purity/Purification: Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH7.4, 0.09% sodium azide, 50% glycerol.
• Concentration: 1 mg/ml (varies by lot)

• Applicable Applications for anti-TRPM2 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (IHC); Other applications not yet tested.
• Application Notes: Recommended Dilution:; ; Western Blot: 1:1000. 1ug/ml detects TrpC7 in 10ug of rat brain lyste using goat anti-mouse IgG (HRP) as secondary antibody.; Immunohistochemistry: 1:1000; Immunofluorescence: 1:100; ; Optimal dilutions to be determined by the researcher.
• Immunogen: Synthetic peptide corresponding to aa 845-862 of human TRPC7. Cellular Location: membrane
• Grade: Affinity Purified
• Preparation and Storage: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-TRPM2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient. They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical force.

Product Categories/Family for anti-TRPM2 antibody

Antibodies; Abs to Receptors; Estrogen

NCBI and Uniprot Product Information

• NCBI GI #: 4507689
• NCBI GeneID: 7226
• NCBI Accession #: NP_003298.1
• NCBI GenBank Nucleotide #: NM_003307.3
• UniProt Accession #: Q9HCX4; Q5KTC2; Q6J3P5; Q96KN6; Q96Q93; D3DSL6; O94759; Q14DR2; Q5KTC1
• NCBI Official Full Name: transient receptor potential cation channel subfamily M member 2
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily M, member 2
• NCBI Official Symbol: TRPM2
• NCBI Official Synonym Symbols: KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; NUDT9L1; MGC133383
• NCBI Protein Information: transient receptor potential cation channel subfamily M member 2; LTrpC-2; OTTHUMP00000038504; OTTHUMP00000038505; OTTHUMP00000109530; OTTHUMP00000207883; transient receptor potential channel 7; long transient receptor potential channel 2; estrogen-responsive element-associated gene 1 protein
• UniProt Protein Name: Transient receptor potential cation channel subfamily M member 2
• Protein Family: Transient receptor potential cation channel subfamily
• UniProt Gene Name: TRPM2
• UniProt Synonym Gene Names: EREG1; KNP3; LTRPC2; TRPC7
• UniProt Entry Name: TRPM2_HUMAN

NCBI Description

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq]

Uniprot Description

TRPM2: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress. Isoform 2 does not seem to be regulated by ADPR. Has ADP-ribose pyrophosphatase activity. Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.13; Membrane protein, multi-pass; Membrane protein, integral; Hydrolase; Transporter; Channel, calcium

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: ADP-ribose diphosphatase activity; calcium channel activity; manganese ion transmembrane transporter activity; sodium channel activity

Biological Process: response to hydroperoxide; metabolic process; calcium ion transport; transmembrane transport