Mouse anti-Human TrpC5 Monoclonal Antibody | anti-TRPC5 antibody

TrpC5 (Short transient receptor potential channel 5, Htrp-5, Htrp5, TRPC5, TRP5)

Cat. Num. AAA605426

• Gene Names: TRPC5; TRP5
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Ascites; Ascites
• Synonyms: TrpC5; Monoclonal Antibody; TrpC5 (Short transient receptor potential channel 5; Htrp-5; Htrp5; TRPC5; TRP5); Anti -TrpC5 (Short transient receptor potential channel 5; anti-TRPC5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: 9G456
• Specificity: Recognizes human TrpC5.
• Purity/Purification: Ascites; Ascites
• Form/Format: Supplied as a lyophilized powder. Reconstitute in 100ul sterile water, 40-50% glycerol.

• Applicable Applications for anti-TRPC5 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.
• Immunogen: Partial recombinant human TrpC5 (aa534-604) with a GST tag.
• Preparation and Storage: Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20 degree C. Aliquot and store at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot detection of human TrpC5 expression in human epidermoid carcinoma whole cell lysate.)

Related Product Information for anti-TRPC5 antibody

It has been demonstrated that TrpC1 and TrpC5 are subunits of a heteromeric neuronal channel in mammalian brain. TrpC5 is thought to form a receptor-activatd non-selective permeant cation channel. It is probably operated by a phosphatidylinositol second messenger system activated by receptor kinases or G-protein coupled receptors. It has also been shown to be calcium-selective and it may be also activated by intracellular calcium store depletion. TrpC5 protein was shown to be present in hippocampal neuronal growth cones, neuronal cell bodies, areas consistent with new synapse formation, and cytoplasmic transport vesicles along neuronal processes. TrpC5 is expressed in brain with higher levels in fetal brain. Influxes of calcium via voltage-gated channels play a role in neuronal outgrowth and it was suggested that TrpC5 is a candidate for the regulation of calcium waves.

Product Categories/Family for anti-TRPC5 antibody

Antibodies; Abs to Ion Channel

NCBI and Uniprot Product Information

• NCBI GI #: 6002474
• NCBI GeneID: 7224
• UniProt Accession #: Q9UL62; O75233; Q5JXY8; Q9Y514; B2RP53; Q59G51
• Molecular Weight: 111,412 Da
• NCBI Official Full Name: transient receptor potential calcium channel 5
• NCBI Official Synonym Full Names: transient receptor potential cation channel, subfamily C, member 5
• NCBI Official Symbol: TRPC5
• NCBI Official Synonym Symbols: TRP5
• NCBI Protein Information: short transient receptor potential channel 5; TRP-5; hTRP5; OTTHUMP00000023863; transient receptor protein 5
• UniProt Protein Name: Short transient receptor potential channel 5
• Protein Family: Short transient receptor potential channel
• UniProt Gene Name: TRPC5
• UniProt Synonym Gene Names: TRP5
• UniProt Entry Name: TRPC5_HUMAN

NCBI Description

This gene belongs to the transient receptor family. It encodes one of the seven mammalian TRPC (transient receptor potential channel) proteins. The encoded protein is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with TRPC1, TRPC3, and TRPC4. It also interacts with multiple proteins including calmodulin, CABP1, enkurin, Na(+)-H+ exchange regulatory factor (NHERF ), interferon-induced GTP-binding protein (MX1), ring finger protein 24 (RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (SESTD1). [provided by RefSeq]

Uniprot Description

TRPC5: Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.

Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq23

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; store-operated calcium channel activity; calcium channel activity

Biological Process: axon guidance; nervous system development; calcium ion transport; transmembrane transport