Mouse anti-Human BACTERICIDAL PERMEABILITY INCREASING PROTEIN Monoclonal Antibody | anti-BPI antibody
BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI, CAP57)
Reactivity
Human
Purity
Affinity PurifiedPurified by Protein G affinity chromatography.
Synonyms
BACTERICIDAL PERMEABILITY INCREASING PROTEIN; Monoclonal Antibody; BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI; CAP57); Anti -BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI; anti-BPI antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
9G128
Specificity
Recognizes full length human natural and recombinant Bactericidal Permeability Increasing protein (BPI). 3F9 recognizes only free BPI and does not interact with BPI that has formed a complex with LPS.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.
Application Notes
Suitable for use in immunoassays both as coating and as detector.
Immunogen
Human BPI.
Preparation and Storage
-20 degree C
Related Product Information for anti-BPI antibody
The antimicrobial protein BPI is a 55kD protein found in the primary (azurophilic) granules of human neutrophils and has also been detected on surface of neutrophils, small intestinal and oral epithelial cells. BPI is a bactericidal compound that is present in polymorphonuclear cells (PMN) and in lower levels in the specific granules of eosinophils. BPI possesses high affinity toward the lipid A region of lipopolysaccharides (LPS) that comprise the outer leaflet of the gram-negative bacterial outer membrane. Binding of BPI to the lipid A moiety of LPS exerts multiple anti-infective activities against gram-negative bacteria: 1) cytotoxicity via sequential damage to bacterial outer and inner lipid membranes, 2) neutralization of gram-negative bacterial LPS, 3) opsonization of bacteria to enhance phagocytosis by neutrophils. Airway epithelial cells constitutively express the BPI gene and produce the BPI protein and, therefore, BPI may be a critical determinant in the development of LPS-triggered airways disease. Inflammation induced by LPS possibly contributes to the development of rapid airflow decline, a serious and often fatal complication of hematopoietic cell transplantation. Furthermore, a 21kD bioactive recombinant fragment of BPI, rBPI21, was shown to confer a survival advantage
Product Categories/Family for anti-BPI antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
53,442 Da
NCBI Official Full Name
bactericidal permeability-increasing protein
NCBI Official Symbol
BPI
NCBI Protein Information
bactericidal permeability-increasing protein
UniProt Protein Name
Bactericidal permeability-increasing protein
Protein Family
UniProt Gene Name
BPI
UniProt Entry Name
BPI_BOVIN
Uniprot Description
Function: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope.
Subunit structure: Monomer. Homodimer; disulfide-linked
Subcellular location: Secreted
By similarity. Cytoplasmic granule membrane
By similarity. Note: Membrane-associated in polymorphonuclear Leukocytes (PMN) granules
Tissue specificity: Restricted to cells of the myeloid series.
Domain: The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested
Sequence similarities: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Research Articles on BPI
Similar Products
Product Notes
The BPI bpi (Catalog #AAA604935) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The BACTERICIDAL PERMEABILITY INCREASING PROTEIN (BPI, CAP57) reacts with Human and may cross-react with other species as described in the data sheet. Suitable for use in immunoassays both as coating and as detector. Researchers should empirically determine the suitability of the BPI bpi for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BACTERICIDAL PERMEABILITY INCREASING PROTEIN, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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