Mouse anti-Human GRIP1 Monoclonal Antibody | anti-GRIP1 antibody

GRIP1 (Glucocorticoid Receptor Interacting Protein 1, NCOA2 TIF2, Transcriptional Intermediary Factor 2) (BSA & Azide Free)

Cat. Num. AAA604698

• Gene Names: GRIP1; GRIP
• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: GRIP1; Monoclonal Antibody; GRIP1 (Glucocorticoid Receptor Interacting Protein 1; NCOA2 TIF2; Transcriptional Intermediary Factor 2) (BSA & Azide Free); Anti -GRIP1 (Glucocorticoid Receptor Interacting Protein 1; anti-GRIP1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1,k
• Clone Number: 3F196
• Specificity: Recognizes human GRIP1 at ~160kD.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in 10mM PBS, pH 7.4. Also available with BSA and sodium azide. See G8970-10.

• Applicable Applications for anti-GRIP1 antibody: Western Blot (WB), Immunoprecipitation (IP)
• Application Notes: Suitable for use in Western Blot and Immunoprecipitation.; Dilution: Western Blot: 1-2ug/ml for 2 hours at RT.; Immunoprecipitation: 2ug/mg protein lysate using Protein G.
• Immunogen: Recombinant human GRIP1 protein. Cellular Localization: Nuclear
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Related Product Information for anti-GRIP1 antibody

The steroid hormones, thyroid hormone, vitamin D, and retinoic acid function by activating specific "nuclear receptor proteins" found inside of target cells. The activated receptors bind to and activate specific genes, and the products of these activated genes change cellular activities in specific ways, thus constituting the biological response to the hormone. After binding to target genes, the activated nuclear receptors require the assistance of proteins called "transcriptional co-activators" in order to activate the target genes. GRIP1 (Glucocorticoid Receptor Interacting Protein 1) is a novel protein that serves as a transcriptional co-activator for steroid and nuclear hormone receptors.

Product Categories/Family for anti-GRIP1 antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 296010842
• NCBI GeneID: 23426
• NCBI Accession #: NP_001171545.1
• NCBI GenBank Nucleotide #: NM_001178074.1
• UniProt Accession #: Q1RLM0; C9JT59; Q9Y3R0
• Molecular Weight: ~160kD
• NCBI Official Full Name: glutamate receptor-interacting protein 1 isoform 2
• NCBI Official Synonym Full Names: glutamate receptor interacting protein 1
• NCBI Official Symbol: GRIP1
• NCBI Official Synonym Symbols: GRIP
• NCBI Protein Information: glutamate receptor-interacting protein 1; OTTHUMP00000239944; OTTHUMP00000239945; OTTHUMP00000239946; OTTHUMP00000239947; OTTHUMP00000239969
• UniProt Protein Name: Glutamate receptor-interacting protein 1
• Protein Family: GRIP1-associated protein
• UniProt Gene Name: GRIP1
• UniProt Entry Name: GRIP1_HUMAN

NCBI Description

This gene encodes a member of the glutamate receptor interacting protein family. The encoded scaffold protein binds to and mediates the trafficking and membrane organization of a number of transmembrane proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]

Uniprot Description

GRIP1: a scaffold protein for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific locations in neurons. Interacts with EphA7, EphB2, KIF5A, -B, -C, GluR2, -3, GRIPAP1, liprin A1, PPFIA4, FRAS1, and PTPRF.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q14.3

Cellular Component: postsynaptic membrane; recycling endosome; neuron projection; endoplasmic reticulum; cytoplasmic membrane-bound vesicle; dendrite; plasma membrane; cytosol; cell junction; lipid raft

Molecular Function: protein C-terminus binding; protein binding; receptor signaling complex scaffold activity; androgen receptor binding; transcription coactivator activity; beta-catenin binding; glucocorticoid receptor binding

Biological Process: synaptic transmission; protein localization; positive regulation of transcription, DNA-dependent; androgen receptor signaling pathway; dendrite development

Disease: Fraser Syndrome