Mouse anti-Human RAD23B Monoclonal Antibody | anti-RAD23B antibody

RAD23B (hHR23B, P58, RAD23 (S. cerevisiae) Homolog B, UV Excision Repair Protein RAD23 Homolog B, XP-C Repair Complementing Complex 58kD, XP-C Repair Complementing Protein)

Cat. Num. AAA602909

• Gene Names: RAD23B; P58; HR23B; HHR23B
• Reactivity: Human
• Applications: Western Blot, Gel Super Shift Assay
• Purity: Affinity Purified; Purified by Protein G affinity chromatography.
• Synonyms: RAD23B; Monoclonal Antibody; RAD23B (hHR23B; P58; RAD23 (S. cerevisiae) Homolog B; UV Excision Repair Protein RAD23 Homolog B; XP-C Repair Complementing Complex 58kD; XP-C Repair Complementing Protein); Anti -RAD23B (hHR23B; anti-RAD23B antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 8J140
• Specificity: Recognizes human RAD23B.
• Purity/Purification: Affinity Purified; Purified by Protein G affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 1% BSA and 0.05% sodium azide.

• Applicable Applications for anti-RAD23B antibody: Western Blot (WB), Gel Shift Assay (GS/EMSA)
• Application Notes: Suitable for use in Dot Blot and Western Blot.
• Immunogen: Partial sequence of recombinant full-length protein to human RAD23B
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Testing Data

Testing Data

Product Categories/Family for anti-RAD23B antibody

Antibodies; Abs to Transcription Factors

NCBI and Uniprot Product Information

• NCBI GI #: 55661957
• NCBI GeneID: 5887
• UniProt Accession #: P54727; Q8WUB0; B3KWK8; Q53F10; Q5W0S4; Q5W0S5; Q7Z5K8
• Molecular Weight: 43,171 Da
• NCBI Official Full Name: RAD23 homolog B (S. cerevisiae)
• NCBI Official Synonym Full Names: RAD23 homolog B (S. cerevisiae)
• NCBI Official Symbol: RAD23B
• NCBI Official Synonym Symbols: P58; HR23B; HHR23B
• NCBI Protein Information: UV excision repair protein RAD23 homolog B; OTTHUMP00000021857; RAD23, yeast homolog of, B; XP-C repair complementing protein; XP-C repair complementing complex 58 kDa; XP-C repair-complementing complex 58 kDa protein
• UniProt Protein Name: UV excision repair protein RAD23 homolog B
• Protein Family: Ubiquitin receptor
• UniProt Gene Name: RAD23B
• UniProt Entry Name: RD23B_HUMAN

NCBI Description

The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. [provided by RefSeq]

Uniprot Description

RAD23B: Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Belongs to the RAD23 family.

Protein type: Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q31.2

Cellular Component: proteasome complex; nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; damaged DNA binding; polyubiquitin binding; single-stranded DNA binding

Biological Process: nucleotide-excision repair, DNA damage recognition; proteasomal ubiquitin-dependent protein catabolic process; nucleotide-excision repair; regulation of proteasomal ubiquitin-dependent protein catabolic process; spermatogenesis; nucleotide-excision repair, DNA damage removal; DNA repair