Mouse anti-Human, Rat Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase Monoclonal Antibody | anti-TPH1 antibody
Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)
Gene Names
TPH1; TPRH; TRPH; MGC119994
Reactivity
Human, Rat
Applications
Western Blot, Immunoprecipitation, Immunohistochemistry
Purity
Affinity PurifiedPurified by Protein G affinity chromatography. Sterile-filtered with a 0.22um filter.
Synonyms
Tryptophan Hydroxylase; Tyrosine Hydroxylase & Phenylalanine Hydroxylase; Monoclonal Antibody; Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH; TYH; TRH; PAH; PH8; Tyrosine 3 Hydroxylase; Tyrosine 3 Monooxygenase); Anti -Tryptophan Hydroxylase; anti-TPH1 antibody
Host
Mouse
Reactivity
Human, Rat
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2Q122
Specificity
Binds a common epitope of human Tryptophan hydroxylase (TRH), Tyrosine hydroxylase (TYH) and Phenylalanine hydroxylase (PAH). Species Crossreactivity: Rat.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography. Sterile-filtered with a 0.22um filter.
Purified by Protein G affinity chromatography. Sterile-filtered with a 0.22um filter.
Form/Format
Supplied as a liquid in PBS, 40% glycerol.
Applicable Applications for anti-TPH1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes
Suitable for use in the identification of dopaminergic and serotonergic neurons by Immunohistochemistry. Also suitable for Western Blot, Immunoprecipitation and Immunohistochemistry of TYH, PAH and TRH.
Dilution: Immunohistochemistry: 1:1000-1:5000
Dilution: Immunohistochemistry: 1:1000-1:5000
Immunogen
Human phenylalanine hydroxylase sequence between aa139-155.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-TPH1 antibody
Tyrosine hydroxylase (TYH) is the enzyme which converts tyrosine to dihydroxyphenylalanine (L-dopa), a precursor of the catecholamine neurotransmitters dopamine, noradrenaline and adrenaline. Tryptophan hydroxylase (TRH) is the enzyme that converts 5-hydroxytryptophan to serotonin.
Product Categories/Family for anti-TPH1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
18,331 Da
NCBI Official Full Name
tryptophan hydroxylase
NCBI Official Synonym Full Names
tryptophan hydroxylase 1
NCBI Official Symbol
TPH1
NCBI Official Synonym Symbols
TPRH; TRPH; MGC119994
NCBI Protein Information
tryptophan 5-hydroxylase 1; OTTHUMP00000232851; L-tryptophan hydroxylase; tryptophan 5-monooxygenase 1; indoleacetic acid-5-hydroxylase; tryptophan hydroxylase (tryptophan 5-monooxygenase)
UniProt Protein Name
Tryptophan hydroxylase
Protein Family
UniProt Entry Name
Q86Y20_HUMAN
NCBI Description
This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
Research Articles on TPH1
Similar Products
Product Notes
The TPH1 (Catalog #AAA602564) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase) reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC). Suitable for use in the identification of dopaminergic and serotonergic neurons by Immunohistochemistry. Also suitable for Western Blot, Immunoprecipitation and Immunohistochemistry of TYH, PAH and TRH. Dilution: Immunohistochemistry: 1:1000-1:5000. Researchers should empirically determine the suitability of the TPH1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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