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Mouse anti-Human Wolf-Hirschhorn Syndrome Candidate 1-like 1 Monoclonal Antibody | anti-WHSC1L1 antibody

Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1, FLJ20353, MGC126766, NSD3, pp14328)

Gene Names
WHSC1L1; NSD3; pp14328; FLJ20353; MGC126766; MGC142029; DKFZp667H044
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity Purified
Purified by Protein G affinity chromatography.
Synonyms
Wolf-Hirschhorn Syndrome Candidate 1-like 1; Monoclonal Antibody; Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1; FLJ20353; MGC126766; NSD3; pp14328); Anti -Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1; anti-WHSC1L1 antibody
Ordering
For Research Use Only!
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
8G3
Specificity
Recognizes human NSD3.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Applicable Applications for anti-WHSC1L1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1,000-1:3,000
Immunogen
Recombinant human NSD3 (383-660aa).
Hybridoma
F0 myeloma cells with spleen cells from BALB/c mice.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Related Product Information for anti-WHSC1L1 antibody
This gene encoding NSD3 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. NSD3 is Histone methyltransferase which preferentially methylates 'Lys-4' and 'Lys-27' of histone H3 and is amplified in several tumor cell lines and primary breast carcinomas.
Product Categories/Family for anti-WHSC1L1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
Molecular Weight
161,613 Da
NCBI Official Full Name
Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Official Synonym Full Names
Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Official Symbol
WHSC1L1
NCBI Official Synonym Symbols
NSD3; pp14328; FLJ20353; MGC126766; MGC142029; DKFZp667H044
NCBI Protein Information
histone-lysine N-methyltransferase NSD3; protein whistle; OTTHUMP00000228478; OTTHUMP00000228479; OTTHUMP00000228480; OTTHUMP00000228487; WHSC1-like protein 1; nuclear SET domain-containing protein 3; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine
UniProt Protein Name
Histone-lysine N-methyltransferase NSD3
UniProt Gene Name
WHSC1L1
UniProt Synonym Gene Names
NSD3
UniProt Entry Name
NSD3_HUMAN

NCBI Description

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described. [provided by RefSeq]

Uniprot Description

WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.

Protein type: Methyltransferase; Amino Acid Metabolism - lysine degradation; Oncoprotein; EC 2.1.1.43; Histone-binding; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: nucleoplasm; chromosome; nucleus

Molecular Function: protein binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific)

Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; histone H3-K4 methylation; negative regulation of transcription, DNA-dependent

Disease: Leukemia, Acute Myeloid

Research Articles on WHSC1L1

Similar Products

Product Notes

The WHSC1L1 whsc1l1 (Catalog #AAA602028) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1, FLJ20353, MGC126766, NSD3, pp14328) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Wolf-Hirschhorn Syndrome Candidate 1-like 1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Dilution: Western Blot: 1:1,000-1:3,000. Researchers should empirically determine the suitability of the WHSC1L1 whsc1l1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Wolf-Hirschhorn Syndrome Candidate 1-like 1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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