Mouse anti-Human Nuclear Protein, Ataxia-telangiectasia Locus Monoclonal Antibody | anti-NPAT antibody
Nuclear Protein, Ataxia-telangiectasia Locus (NPAT)
Purified by Protein G affinity chromatography.
Purified by Protein G affinity chromatography.
NCBI and Uniprot Product Information
Uniprot Description
NPAT: nuclear protein of the ATM locus is required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and DNA-PK promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Induced by the expression of E2F1, E2F2, E2F3 and E2F4. Expression is reduced in response to radiation-induced DNA damage. Expression peaks at the G1/S phase boundary and declines during S phase. Interacts with the cylin/CDK complexes CCNE1/CDK2 and CCNA1/CDK2. Interacts with BZW1, CASP8AP2, CREBBP, MIZF and YY1. Interacts with the RUVBL1, RUVBL2 and TRRAP subunits of the NuA4 complex. May also interact with GAPDH, NME1, NME2 and STIP1. Belongs to the NPAT family.
Protein type: Transcription regulation; Cell cycle regulation
Chromosomal Location of Human Ortholog: 11q22-q23
Cellular Component: nucleoplasm; Cajal body; cytoplasm; nucleus
Molecular Function: protein C-terminus binding; protein binding; transcription coactivator activity; protein N-terminus binding; transcription corepressor activity
Biological Process: G1/S-specific transcription in mitotic cell cycle; transcription, DNA-dependent; regulation of gene expression; positive regulation of transcription, DNA-dependent
Research Articles on NPAT
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Product Notes
The NPAT npat (Catalog #AAA601789) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Nuclear Protein, Ataxia-telangiectasia Locus (NPAT) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Nuclear Protein, Ataxia-telangiectasia Locus can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Gel Shift Assay (GS/EMSA). Suitable for use in Dot Blot and Western Blot. Researchers should empirically determine the suitability of the NPAT npat for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Nuclear Protein, Ataxia-telangiectasia Locus, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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