Western Blot (WB)
(CHST14 Antibody (Center) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the CHST14 antibody detected CHST14 protein (arrow).)
Rabbit anti-Mouse CHST14 Polyclonal Antibody | anti-CHST14 antibody
CHST14, ID (CHST14, D4ST1, Carbohydrate sulfotransferase 14, Dermatan 4-sulfotransferase 1)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Western Blot (WB)
(CHST14 Antibody (Center) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the CHST14 antibody detected CHST14 protein (arrow).)
Western Blot (WB)
(CHST14 Antibody (Center) western blot analysis in mouse stomach tissue lysates (15ug/lane).This demonstrates the CHST14 antibody detected CHST14 protein (arrow).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Uniprot Description
CHST14: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. GlcUA to IdoUA. Appears to have an important role in the formation of the cerbellar neural network during postnatal brain development. Defects in CHST14 are the cause of Ehlers-Danlos syndrome musculocontractural type (EDSMC). It is a form of Ehlers-Danlos syndrome characterized by distinctive craniofacial dysmorphism, congenital contractures of thumbs and fingers, clubfeet, severe kyphoscoliosis, muscular hypotonia, hyperextensible thin skin with easy bruisability and atrophic scarring, wrinkled palms, joint hypermobility, and ocular involvement. Belongs to the sulfotransferase 2 family.
Protein type: Glycan Metabolism - chondroitin sulfate biosynthesis; Transferase; Membrane protein, integral; EC 2.8.2.35
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: Golgi membrane; integral to membrane
Molecular Function: N-acetylgalactosamine 4-O-sulfotransferase activity; phosphate binding
Biological Process: chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; dermatan sulfate proteoglycan metabolic process; carbohydrate metabolic process; pathogenesis; carbohydrate biosynthetic process; dermatan sulfate biosynthetic process
Disease: Ehlers-danlos Syndrome, Musculocontractural Type 1
Research Articles on CHST14
Similar Products
Product Notes
The CHST14 chst14 (Catalog #AAA6013652) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CHST14, ID (CHST14, D4ST1, Carbohydrate sulfotransferase 14, Dermatan 4-sulfotransferase 1) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CHST14 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the CHST14 chst14 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CHST14, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
