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Western Blot (WB) (DND1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the DND1 antibody detected the DND1 protein (arrow).)

Rabbit anti-Human DND1 Polyclonal Antibody | anti-DND1 antibody

DND1, ID (DND1, RBMS4, Dead end protein homolog 1, RNA-binding motif, single-stranded-interacting protein 4)

Gene Names
DND1; ATCNGC2; CNGC2; CYCLIC NUCLEOTIDE GATED CHANNEL 2; CYCLIC NUCLEOTIDE-GATED CHANNEL 2; DEFENSE NO DEATH 1; DND1
Reactivity
Human
Applications
ELISA, Western Blot
Purity
Affinity Purified
Purified by Protein A affinity chromatography.
Synonyms
DND1; Polyclonal Antibody; ID (DND1; RBMS4; Dead end protein homolog 1; RNA-binding motif; single-stranded-interacting protein 4); Anti -DND1; anti-DND1 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Specificity
Human
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Applicable Applications for anti-DND1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunogen
DND1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 197-226 amino acids from the Central region of human DND1.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(DND1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the DND1 antibody detected the DND1 protein (arrow).)

Western Blot (WB) (DND1 Antibody (Center) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the DND1 antibody detected the DND1 protein (arrow).)
Related Product Information for anti-DND1 antibody
This gene encodes a protein that binds to microRNA-targeting sequences of mRNAs, inhibiting microRNA-mediated repression. Reduced expression of this gene has been implicated in tongue squamous cell carcinoma. Two pseudogenes of this gene are located on the long arm of chromosome 17.
Product Categories/Family for anti-DND1 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
83,241 Da
NCBI Official Full Name
DND1
NCBI Official Symbol
DND1
NCBI Official Synonym Symbols
ATCNGC2; CNGC2; CYCLIC NUCLEOTIDE GATED CHANNEL 2; CYCLIC NUCLEOTIDE-GATED CHANNEL 2; DEFENSE NO DEATH 1; DND1
NCBI Protein Information
cyclic nucleotide-gated ion channel 2
UniProt Protein Name
Cyclic nucleotide-gated ion channel 2
Protein Family
UniProt Gene Name
CNGC2
UniProt Synonym Gene Names
DND1; AtCNGC2
UniProt Entry Name
CNGC2_ARATH

Uniprot Description

Function: Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium, cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis, re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs. Ref.3 Ref.8

Subunit structure: Homotetramer or heterotetramer

Potential. Binds calmodulin-1/4 with a higher affinity than calmodulin-2/3/5.

Subcellular location: Cell membrane; Multi-pass membrane protein

Potential.

Tissue specificity: Expressed in the whole plant but only weakly in roots. Strongly expressed in the expanded cotyledons of 14-day-old seedlings and detected later in leaves after the transition to flowering. Also detected in flowers during organ senescence and in the dehiscence zone of siliques. Ref.8

Induction: Up-regulated by light. Transiently induced during leaf and culture senescence. Ref.8

Domain: The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation

By similarity. Ref.7

Miscellaneous: Loss-of-function mutations cngc2-1 (dnd1-1) or cncg2-2 results in the loss of the hypersensitive response and leads to a broad spectrum disease resistance. These mutations lead to a specific and dramatic calcium hypersensitivity that results in severe reductions in plant size and seed yield.

Sequence similarities: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. [View classification]Contains 1 cyclic nucleotide-binding domain.Contains 1 IQ domain.

Research Articles on DND1

Similar Products

Product Notes

The DND1 cngc2 (Catalog #AAA6012510) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The DND1, ID (DND1, RBMS4, Dead end protein homolog 1, RNA-binding motif, single-stranded-interacting protein 4) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's DND1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in Western Blot, ELISA Dilution: ELISA: 1:1,000 Western Blot: 1:100-500. Researchers should empirically determine the suitability of the DND1 cngc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "DND1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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