Western Blot (WB)
(Western Blot detection against Immunogen (36.34kD).)
Mouse DND1 Monoclonal Antibody | anti-DND1 antibody
DND1 (RBMS4, Dead End Protein Homolog 1, RNA-binding Motif, Single-stranded-interacting Protein 4, MGC34750)
Purified by Protein A affinity chromatography.
Purified by Protein A affinity chromatography.
Western Blot (WB)
(Western Blot detection against Immunogen (36.34kD).)
Western Blot (WB)
(Western Blot detection against Immunogen (36.34kD).)
Western Blot (WB)
(DND1 monoclonal antibody. Western Blot analysis of DND1 expression in PC-12.)
Western Blot (WB)
(DND1 monoclonal antibody. Western Blot analysis of DND1 expression in PC-12.)
Western Blot (WB)
(DND1 monoclonal antibody Western Blot analysis of DND1 expression in Hela NE.)
Western Blot (WB)
(DND1 monoclonal antibody Western Blot analysis of DND1 expression in Hela NE.)
Western Blot (WB)
(DND1 monoclonal antibody Western Blot analysis of DND1 expression in Raw 264.7.)
Western Blot (WB)
(DND1 monoclonal antibody Western Blot analysis of DND1 expression in Raw 264.7.)
Western Blot (WB)
(DND1 monoclonal antibody Western Blot analysis of DND1 expression in NIH/3T3.)
Western Blot (WB)
(DND1 monoclonal antibody Western Blot analysis of DND1 expression in NIH/3T3.)
NCBI and Uniprot Product Information
Uniprot Description
Function: Acts as cyclic nucleotide-gated ion channel. Permeable to potassium and calcium in a cyclic nucleotide-dependent fashion (cAMP or cGMP). Could also transport lithium, cesium and rubium and displays a strong selectivity against sodium. Seems to directly participate in pathogen-induced calcium influx. May function in homeostasis, re-establishing ionic balance after defense action and/or other stimuli. Could mediate the initiation of the developmentally regulated cell death programs. Ref.3 Ref.8
Subunit structure: Homotetramer or heterotetramer
Potential. Binds calmodulin-1/4 with a higher affinity than calmodulin-2/3/5.
Subcellular location: Cell membrane; Multi-pass membrane protein
Potential.
Tissue specificity: Expressed in the whole plant but only weakly in roots. Strongly expressed in the expanded cotyledons of 14-day-old seedlings and detected later in leaves after the transition to flowering. Also detected in flowers during organ senescence and in the dehiscence zone of siliques. Ref.8
Induction: Up-regulated by light. Transiently induced during leaf and culture senescence. Ref.8
Domain: The binding of calmodulin to the C-terminus might interfere with cyclic nucleotide binding and thus channel activation
By similarity. Ref.7
Miscellaneous: Loss-of-function mutations cngc2-1 (dnd1-1) or cncg2-2 results in the loss of the hypersensitive response and leads to a broad spectrum disease resistance. These mutations lead to a specific and dramatic calcium hypersensitivity that results in severe reductions in plant size and seed yield.
Sequence similarities: Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. [View classification]Contains 1 cyclic nucleotide-binding domain.Contains 1 IQ domain.
Research Articles on DND1
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Product Notes
The DND1 cngc2 (Catalog #AAA645393) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The DND1 (RBMS4, Dead End Protein Homolog 1, RNA-binding Motif, Single-stranded-interacting Protein 4, MGC34750) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's DND1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Western Blot (WB). Suitable for use in ELISA and Western Blot. Researchers should empirically determine the suitability of the DND1 cngc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: EARLLPSPGP APGQIALLKF SSHRAAAMAK KALVEGQSHL CGEQVAVEWL KPDLKQRLRQ QLVGPFLRSP QPEGSQLALA RDKLGFQGAR ATLQ. It is sometimes possible for the material contained within the vial of "DND1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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