Immunohistochemistry (IHC)
(Human Breast (formalin-fixed, paraffin-embedded) stained with NET1 antibody at 2.5ug/ml followed by biotinylated anti-goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Goat anti-Human NET1 Polyclonal Antibody | anti-NET1 antibody
NET1, ID (Neuroepithelial Cell-transforming Gene 1 Protein, Proto-oncogene p65 Net1, Rho Guanine Nucleotide Exchange Factor 8, ARHGEF8)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: ELISA: 1:16,000
Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml
Immunohistochemistry (IHC)
(Human Breast (formalin-fixed, paraffin-embedded) stained with NET1 antibody at 2.5ug/ml followed by biotinylated anti-goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
Immunohistochemistry (IHC)
(Human Breast (formalin-fixed, paraffin-embedded) stained with NET1 antibody at 2.5ug/ml followed by biotinylated anti-goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)
NCBI and Uniprot Product Information
NCBI Description
This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Uniprot Description
NET1: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs; Motility/polarity/chemotaxis; GEFs, Rac/Rho; Oncoprotein
Chromosomal Location of Human Ortholog: 10p15
Cellular Component: plasma membrane; cytosol; nucleus
Molecular Function: Rho guanyl-nucleotide exchange factor activity; guanyl-nucleotide exchange factor activity; GTP-Rho binding
Biological Process: regulation of small GTPase mediated signal transduction; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; myoblast migration; regulation of cell growth; signal transduction
Research Articles on NET1
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Product Notes
The NET1 net1 (Catalog #AAA6011067) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The NET1, ID (Neuroepithelial Cell-transforming Gene 1 Protein, Proto-oncogene p65 Net1, Rho Guanine Nucleotide Exchange Factor 8, ARHGEF8) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's NET1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunohistochemistry (IHC). Suitable for use in ELISA and Immunohistochemistry. Dilution: ELISA: 1:16,000 Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml. Researchers should empirically determine the suitability of the NET1 net1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "NET1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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