Rabbit HtrA2/Omi Polyclonal Antibody | anti-HtrA2 antibody
HtrA2/Omi (HTRA2, HtrA2, PARK13, OMI, PRSS25)
Purified by affinity chromatography.
Purified by affinity chromatography.
Dilution: Immunofluorescence: 20ug/ml
Western Blot: 1-2ug/ml
NCBI and Uniprot Product Information
Uniprot Description
Function: Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th. Ref.1 Ref.2 Ref.3
Catalytic activity: Cleavage of non-polar aliphatic amino-acids at the P1 position, with a preference for Val, Ile and Met. At the P2 and P3 positions, Arg is selected most strongly with a secondary preference for other hydrophilic residues.
Subunit structure: Interacts with th/DIAP1 (via BIR 2 domain). Ref.3
Subcellular location: Mitochondrion intermembrane space; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein
Potential. Note: Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment. The extramitochondrial protein does not diffuse throughout the cytosol but stays near the mitochondria. Ref.1 Ref.3
Developmental stage: Expressed during all stages of development; high in embryos, declined in larvae and pupae and high again in adults. Ref.1 Ref.2
Post-translational modification: Ubiquitinated by th, thereby antagonizing induced cell death.Autoproteolytically cleaved into active forms in the mitochondria. Ref.2 Ref.3
Sequence similarities: Belongs to the peptidase S1B family.Contains 1 PDZ (DHR) domain.
Research Articles on HtrA2
Similar Products
Product Notes
The HtrA2 htra2 (Catalog #AAA6009947) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HtrA2/Omi (HTRA2, HtrA2, PARK13, OMI, PRSS25) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HtrA2/Omi can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). Suitable for use in Immunofluorescence and Western Blot. Dilution: Immunofluorescence: 20ug/ml Western Blot: 1-2ug/ml. Researchers should empirically determine the suitability of the HtrA2 htra2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HtrA2/Omi, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
