Mouse anti-Human CD126 Monoclonal Antibody
CD126 (Interleukin 6 Receptor, neutralizing, IL-6R)
Reactivity
Human
Applications
ELISA, Immunoprecipitation, Immunohistochemistry, Flow Cytometry, Functional Assay
Purity
Highly PurifiedPurified by Ion Exchange chromatography.
Synonyms
CD126; Monoclonal Antibody; CD126 (Interleukin 6 Receptor; neutralizing; IL-6R); Anti -CD126 (Interleukin 6 Receptor; anti-CD126 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2Q1481
Specificity
Recognizes both the soluble and membrane bound human IL-6 receptor. B-R6 will inhibit IL-6 mediated proliferation of XG-1 cells and partially blocks the binding of IL-6 to its receptor.
Purity/Purification
Highly Purified
Purified by Ion Exchange chromatography.
Purified by Ion Exchange chromatography.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Applicable Applications for anti-CD126 antibody
ELISA (EL/EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)
Application Notes
Suitable for use in Flow Cytometry, ELISA, Immunoprecipitation and Immunohistochemistry.
Dilution: Immunohistochemistry: Frozen tissues
Flow Cytometry: 1:50; Use 10ul per 10e6 cells in 100ul
Dilution: Immunohistochemistry: Frozen tissues
Flow Cytometry: 1:50; Use 10ul per 10e6 cells in 100ul
Immunogen
CHO cells transfected with cDNA of the human IL-6 receptor.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Related Product Information for anti-CD126 antibody
The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component speci c to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low af nity binding sites for IL-6, is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. CD126 is single chain type I transmembrane protein with Mr=130-140kD and is a common receptor subunit for many cytokines, forming complexes with CD126, IL-11R, LIF-R, and other proteins. These gp130-containing complexes mediate signaling of oncostatin M, IL-6, IL-11, LIF, CNF, and cardiolipotrophin 1. gp130 is expressed at low levels by most cell types. This antibody was recognized as reacting with gp130 at the Sixth Leucocyte Typing Workshop.
Product Categories/Family for anti-CD126 antibody
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Product Notes
The CD126 (Catalog #AAA600862) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD126 (Interleukin 6 Receptor, neutralizing, IL-6R) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD126 can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS). Suitable for use in Flow Cytometry, ELISA, Immunoprecipitation and Immunohistochemistry. Dilution: Immunohistochemistry: Frozen tissues Flow Cytometry: 1:50; Use 10ul per 10e6 cells in 100ul. Researchers should empirically determine the suitability of the CD126 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD126, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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